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Open AccessReview

Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review

1
Voxdale bv, Bijkhoevelaan 32C, 2110 Wijnegem, Belgium
2
Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1 S.7, 2610 Antwerp, Belgium
3
Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(6), 517; https://doi.org/10.3390/pharmaceutics12060517
Received: 4 May 2020 / Revised: 27 May 2020 / Accepted: 3 June 2020 / Published: 5 June 2020
(This article belongs to the Collection 3D Printing and Bioprinting Applications in Pharmaceutics)
Fused filament fabrication (FFF) 3D printing technology is widely used in many fields. For almost a decade, medical researchers have been exploring the potential use of this technology for improving the healthcare sector. Advances in personalized medicine have been more achievable due to the applicability of producing drug delivery devices, which are explicitly designed based on patients’ needs. For the production of these devices, a filament—which is the feedstock for the FFF 3D printer—consists of a carrier polymer (or polymers) and a loaded active pharmaceutical ingredient (API). This systematic review of the literature investigates the most widely used approaches for producing drug-loaded filaments. It also focusses on several factors, such as the polymeric carrier and the drug, loading capacity and homogeneity, processing conditions, and the intended applications. This review concludes that the filament preparation method has a significant effect on both the drug homogeneity within the polymeric carrier and drug loading efficiency. View Full-Text
Keywords: hot melt extrusion; additive manufacturing; fused filament fabrication; fused deposition modeling; 3D printing; drug loading; drug delivery hot melt extrusion; additive manufacturing; fused filament fabrication; fused deposition modeling; 3D printing; drug loading; drug delivery
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MDPI and ACS Style

Shaqour, B.; Samaro, A.; Verleije, B.; Beyers, K.; Vervaet, C.; Cos, P. Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review. Pharmaceutics 2020, 12, 517. https://doi.org/10.3390/pharmaceutics12060517

AMA Style

Shaqour B, Samaro A, Verleije B, Beyers K, Vervaet C, Cos P. Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review. Pharmaceutics. 2020; 12(6):517. https://doi.org/10.3390/pharmaceutics12060517

Chicago/Turabian Style

Shaqour, Bahaa; Samaro, Aseel; Verleije, Bart; Beyers, Koen; Vervaet, Chris; Cos, Paul. 2020. "Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review" Pharmaceutics 12, no. 6: 517. https://doi.org/10.3390/pharmaceutics12060517

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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