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Open AccessArticle

In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier

1
Department of Pharmacy, Uppsala Biomedical Centre P.O. Box 580, Uppsala University, SE-751 23 Uppsala, Sweden
2
University of South Australia, UniSA: Clinical and Health Sciences, Adelaide SA 5000, Australia
3
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of South Australia, Adelaide SA 5000, Australia
4
Division of Nanotechnology and Functional Materials, Department of Engineering Sciences, Uppsala University, SE-75121 Uppsala, Sweden
5
Department of Chemistry-Biomedical Centre P.O. Box 576, Uppsala University, SE-751 23 Uppsala, Sweden
6
The Swedish Drug Delivery Center, Department of Pharmacy, Uppsala Biomedical Centre P.O. Box 580, Uppsala University, SE-751 23 Uppsala, Sweden
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(5), 426; https://doi.org/10.3390/pharmaceutics12050426
Received: 27 February 2020 / Revised: 29 April 2020 / Accepted: 4 May 2020 / Published: 6 May 2020
(This article belongs to the Special Issue Hybrid Multifunctional Drug Delivery Systems)
Lipid-based formulations can circumvent the low aqueous solubility of problematic drug compounds and increase their oral absorption. As these formulations are often physically unstable and costly to manufacture, solidification has been suggested as a way to minimize these issues. This study evaluated the physicochemical stability and in vitro performance of lipid-loaded mesoporous magnesium carbonate (MMC) particles with an average pore size of 20 nm. A medium chain lipid was loaded onto the MMC carrier via physical adsorption. A modified in vitro lipolysis setup was then used to study lipid release and digestion with 1H nuclear magnetic resonance spectroscopy. The lipid loading efficiency with different solidification techniques was also evaluated. The MMC, unlike more commonly used porous silicate carriers, dissolved during the lipolysis assay, providing a rapid release of encapsulated lipids into solution. The digestion of the dispersed lipid-loaded MMC therefore resembled that of a coarse dispersion of the lipid. The stability data demonstrated minor degradation of the lipid within the pores of the MMC particles, but storage for three months did not reveal extensive degradation. To conclude, lipids can be adsorbed onto MMC, creating a solid powder from which the lipid is readily released into the solution during in vitro digestion. The chemical stability of the formulation does however merit further attention. View Full-Text
Keywords: mesoporous magnesium carbonate; lipid-based formulations; solidification; lipid release; lipolysis; 1H nuclear magnetic resonance mesoporous magnesium carbonate; lipid-based formulations; solidification; lipid release; lipolysis; 1H nuclear magnetic resonance
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MDPI and ACS Style

Alvebratt, C.; Dening, T.J.; Åhlén, M.; Cheung, O.; Strømme, M.; Gogoll, A.; Prestidge, C.A.; Bergström, C.A. In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier. Pharmaceutics 2020, 12, 426.

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