Next Article in Journal
Systematic Development and Optimization of Inhalable Pirfenidone Liposomes for Non-Small Cell Lung Cancer Treatment
Next Article in Special Issue
Solid-in-Oil Nanodispersions for Transcutaneous Immunotherapy of Japanese Cedar Pollinosis
Previous Article in Journal
NIR Laser-Responsive PNIPAM and Gold Nanorod Composites for the Engineering of Thermally Reactive Drug Delivery Nanomedicine
Previous Article in Special Issue
Transcutaneous Delivery of Immunomodulating Pollen Extract-Galactomannan Conjugate by Solid-in-Oil Nanodispersions for Pollinosis Immunotherapy
Open AccessArticle

A Solid-in-Oil Nanodispersion System for Transcutaneous Immunotherapy of Cow’s Milk Allergies

1
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Fukuoka 819-0395, Japan
2
Advanced Transdermal Drug Delivery System Center, Kyushu University, Fukuoka 819-0395, Japan
3
Center for Future Chemistry, Kyushu University, Fukuoka 819-0395, Japan
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(3), 205; https://doi.org/10.3390/pharmaceutics12030205
Received: 16 January 2020 / Revised: 21 February 2020 / Accepted: 25 February 2020 / Published: 27 February 2020
(This article belongs to the Special Issue Nanoparticle-Based Drug Delivery Systems for Immunomodulation)
An allergy to cow’s milk proteins is the most common food allergy in infants and toddlers. Conventional oral immunotherapy for cow’s milk allergies requires hospital admission due to the risk of severe allergic reactions, including anaphylaxis. Therefore, a simpler and safer immunotherapeutic method is desirable. We examined transcutaneous immunotherapy with a solid-in-oil (S/O) system. In the S/O system, nano-sized particles of proteins are dispersed in an oil-vehicle with the assistance of nonionic surfactants. In the present study, the S/O system enhanced the skin permeation of the allergen molecule β-lactoglobulin (BLG), as compared with a control PBS solution. The patches containing BLG in the S/O nanodispersion skewed the immune response in the allergy model mice toward T helper type 1 immunity, indicating the amelioration of allergic symptoms. This effect was more pronounced when the immunomodulator resiquimod (R-848) was included in the S/O system. View Full-Text
Keywords: cow’s milk allergy; whey; solid-in-oil nanodispersions; transcutaneous immunotherapy; vaccine; nanocarrier cow’s milk allergy; whey; solid-in-oil nanodispersions; transcutaneous immunotherapy; vaccine; nanocarrier
Show Figures

Graphical abstract

MDPI and ACS Style

Kitaoka, M.; Xiao, W.; Kong, Q.; Tahara, Y.; Kamiya, N.; Goto, M. A Solid-in-Oil Nanodispersion System for Transcutaneous Immunotherapy of Cow’s Milk Allergies. Pharmaceutics 2020, 12, 205.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop