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Open AccessArticle

Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6845, Australia
Faculty of Pharmacy, Sanata Dharma University, Yogyakarta 55282, Indonesia
Therapeutics Research Centre, Faculty of Medicine, The University of Queensland Diamantina Institute, Woolloongabba 4102, Australia
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5000, Australia
Therapeutics Research Centre, Basil Hetzel Institute for Translational Medical Research, The Queen Elizabeth Hospital, Adelaide 5011, Australia
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(2), 108;
Received: 19 December 2019 / Revised: 20 January 2020 / Accepted: 26 January 2020 / Published: 29 January 2020
Resveratrol (RSV) is a potent lipophilic antioxidant with a low aqueous solubility. Novel nanoformulations have been successfully developed and evaluated to increase the potential of resveratrol as a skin targeting antioxidant. Nanoformulations were prepared using a spontaneous emulsification method, and characterized and evaluated for their capabilities to penetrate/permeate the skin. In nanoformulations, the thermodynamic activity of the RSV penetration into/permeation through the skin was correlated with the thermodynamic activity of the RSV in the formulations. When terpenes were incorporated into the nanoformulations, the permeation of RSV through the skin increased and correlated with an increasing lipophilicity of the terpene. The nanoemulsion containing eugenol showed the highest RSV penetration into the stratum corneum (SC) and the epidermis-dermis-follicle region, whereas the limonene containing nanoemulsion had the highest RSV permeation through the skin (the enhancement ratios, compared to a saturated solution of RSV, were (i) 9.55 and (ii) 12.61, respectively, based on the average RSV amount (i) in each skin region and (ii) permeation through skin). View Full-Text
Keywords: nanocarriers; targeted delivery; skin permeation; resveratrol; antioxidant nanocarriers; targeted delivery; skin permeation; resveratrol; antioxidant
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MDPI and ACS Style

Nastiti, C.M.R.R.; Ponto, T.; Mohammed, Y.; Roberts, M.S.; Benson, H.A.E. Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol. Pharmaceutics 2020, 12, 108.

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