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Open AccessReview

Polysaccharides in Ocular Drug Delivery

1
Institute of Macromolecular Compounds of the Russian Academy of Sciences, Bolshoy pr. V.O. 31, 199004 St. Petersburg, Russia
2
Institute of Chemistry, St. Petersburg State University, Universitetskii pr. 26, Petrodvorets, 198504 St. Petersburg, Russia
3
Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014 Helsinki, Finland
4
School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70210 Kuopio, Finland
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(1), 22; https://doi.org/10.3390/pharmaceutics12010022
Received: 5 December 2019 / Revised: 19 December 2019 / Accepted: 22 December 2019 / Published: 24 December 2019
(This article belongs to the Special Issue Ocular Drug Delivery: Present Innovations and Future Challenges)
Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as polysaccharide derivatives, have been successfully used to augment drug delivery in the treatment of ocular pathologies. The properties of polysaccharides can be extensively modified to optimize ocular drug formulations and to obtain biocompatible and biodegradable drugs with improved bioavailability and tailored pharmacological effects. This review discusses the available polysaccharide choices for overcoming the difficulties associated with ocular drug delivery, and it explores the reasons for the dependence between the physicochemical properties of polysaccharide-based drug carriers and their efficiency in different formulations and applications. Polysaccharides will continue to be of great interest to researchers endeavoring to develop ophthalmic drugs with improved effectiveness and safety. View Full-Text
Keywords: eye tissue regeneration; intravitreal administration; ocular bioavailability; ocular drug delivery; periocular administration; polysaccharide; topical administration eye tissue regeneration; intravitreal administration; ocular bioavailability; ocular drug delivery; periocular administration; polysaccharide; topical administration
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MDPI and ACS Style

Dubashynskaya, N.; Poshina, D.; Raik, S.; Urtti, A.; Skorik, Y.A. Polysaccharides in Ocular Drug Delivery. Pharmaceutics 2020, 12, 22.

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