Next Article in Journal
Functional Role of VCAM-1 Targeted Flavonoid-Loaded Lipid Nanoemulsions in Reducing Endothelium Inflammation
Previous Article in Journal
Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications
Previous Article in Special Issue
Towards Printed Pediatric Medicines in Hospital Pharmacies: Comparison of 2D and 3D-Printed Orodispersible Warfarin Films with Conventional Oral Powders in Unit Dose Sachets
Open AccessReview

Application of Micro-Scale 3D Printing in Pharmaceutics

Department of Biological Engineering, Utah State University, Logan, UT 84322, USA
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(8), 390; https://doi.org/10.3390/pharmaceutics11080390
Received: 30 June 2019 / Revised: 28 July 2019 / Accepted: 1 August 2019 / Published: 3 August 2019
(This article belongs to the Special Issue 3D Printing of Pharmaceuticals and Drug Delivery Devices)
  |  
PDF [3170 KB, uploaded 3 August 2019]
  |  

Abstract

3D printing, as one of the most rapidly-evolving fabrication technologies, has released a cascade of innovation in the last two decades. In the pharmaceutical field, the integration of 3D printing technology has offered unique advantages, especially at the micro-scale. When printed at a micro-scale, materials and devices can provide nuanced solutions to controlled release, minimally invasive delivery, high-precision targeting, biomimetic models for drug discovery and development, and future opportunities for personalized medicine. This review aims to cover the recent advances in this area. First, the 3D printing techniques are introduced with respect to the technical parameters and features that are uniquely related to each stage of pharmaceutical development. Then specific micro-sized pharmaceutical applications of 3D printing are summarized and grouped according to the provided benefits. Both advantages and challenges are discussed for each application. We believe that these technologies provide compelling future solutions for modern medicine, while challenges remain for scale-up and regulatory approval. View Full-Text
Keywords: additive manufacturing; 3D printing; drug delivery; micromedicine; drug development; micro-swimmer; micro-implant; oral dosages; microneedle; high-precision targeting; controlled release; geometry; resolution; feature size; personalized medicine; release profile; vascularization additive manufacturing; 3D printing; drug delivery; micromedicine; drug development; micro-swimmer; micro-implant; oral dosages; microneedle; high-precision targeting; controlled release; geometry; resolution; feature size; personalized medicine; release profile; vascularization
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Kjar, A.; Huang, Y. Application of Micro-Scale 3D Printing in Pharmaceutics. Pharmaceutics 2019, 11, 390.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top