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Open AccessArticle

Additive Manufacturing of Personalized Pharmaceutical Dosage Forms via Stereolithography

1
Materials Research Institute, Athlone Institute of Technology, Dublin Road, Athlone, Co., Westmeath N37 HD68, Ireland
2
Applied Polymer Technologies Gateway, Athlone Institute of Technology, Dublin Road, Athlone, Co., Westmeath N37 HD68, Ireland
3
Faculty of Engineering and Informatics, Athlone Institute of Technology, Dublin Road, Athlone, Co., Westmeath N37 HD68, Ireland
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(12), 645; https://doi.org/10.3390/pharmaceutics11120645
Received: 18 October 2019 / Revised: 25 November 2019 / Accepted: 28 November 2019 / Published: 3 December 2019
(This article belongs to the Special Issue 3D Printing of Pharmaceuticals and Drug Delivery Devices)
The introduction of three-dimensional printing (3DP) has created exciting possibilities for the fabrication of dosage forms, paving the way for personalized medicine. In this study, oral dosage forms of two drug concentrations, namely 2.50% and 5.00%, were fabricated via stereolithography (SLA) using a novel photopolymerizable resin formulation based on a monomer mixture that, to date, has not been reported in the literature, with paracetamol and aspirin selected as model drugs. In order to produce the dosage forms, the ratio of poly(ethylene glycol) diacrylate (PEGDA) to poly(caprolactone) triol was varied with diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (Irgacure TPO) utilized as the photoinitiator. The fabrication of 28 dosages in one print process was possible and the printed dosage forms were characterized for their drug release properties. It was established that both drugs displayed a sustained release over a 24-h period. The physical properties were also investigated, illustrating that SLA affords accurate printing of dosages with some statistically significant differences observed from the targeted dimensional range, indicating an area for future process improvement. The work presented in this paper demonstrates that SLA has the ability to produce small, individualized batches which may be tailored to meet patients’ specific needs or provide for the localized production of pharmaceutical dosage forms. View Full-Text
Keywords: stereolithography; three-dimensional printing; additive manufacturing; personalized medicine; 3D printed oral dosage forms; drug delivery; sustained drug release tablets; photopolymerization; paracetamol (acetaminophen); aspirin (acetylsalicylic acid) stereolithography; three-dimensional printing; additive manufacturing; personalized medicine; 3D printed oral dosage forms; drug delivery; sustained drug release tablets; photopolymerization; paracetamol (acetaminophen); aspirin (acetylsalicylic acid)
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MDPI and ACS Style

Healy, A.V.; Fuenmayor, E.; Doran, P.; Geever, L.M.; Higginbotham, C.L.; Lyons, J.G. Additive Manufacturing of Personalized Pharmaceutical Dosage Forms via Stereolithography. Pharmaceutics 2019, 11, 645.

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