Development and In Vivo Evaluation of Multidrug Ultradeformable Vesicles for the Treatment of Skin Inflammation
by
Roberto Molinaro 1
, Agnese Gagliardi 2, Antonia Mancuso 3, 
Donato Cosco 3, Mahmoud E. Soliman 4, Luca Casettari 1,* and 
Donatella Paolino 2,*
Roberto Molinaro 1, Agnese Gagliardi 2, Antonia Mancuso 3, Donato Cosco 3, Mahmoud E. Soliman 4, Luca Casettari 1,* and Donatella Paolino 2,*
1
Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino (PU), Italy
2
Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Loc. Germaneto I-88100 Catanzaro, Italy
3
Health Sciences Department, University Magna Graecia of Catanzaro, Loc. Germaneto I-88100 Catanzaro, Italy
4
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2019, 11(12), 644; https://doi.org/10.3390/pharmaceutics11120644
Received: 14 October 2019 / Revised: 22 November 2019 / Accepted: 25 November 2019 / Published: 3 December 2019
(This article belongs to the Special Issue Non-Invasive Drug Delivery Systems)
The aim of this work was to evaluate the effect of two chemically different edge activators, i.e., Tween® 80 and sodium deoxycholate, on (i) the physical, mechanical, and biological properties of ultradeformable vesicles, and (ii) the administration of naproxen sodium-loaded multidrug ultradeformable vesicles for the transdermal route in order to obtain therapeutically meaningful drug concentrations in the target tissues and to potentiate its anti-inflammatory effect by association with the antioxidant drug idebenone. The results obtained in this investigation highlighted a synergistic action between naproxen and idebenone in the treatment of inflammatory disease with a more pronounced anti-inflammatory effect in multidrug ultradeformable vesicles compared to the commercial formulation of Naprosyn® gel. Systems made up of Tween® 80 appeared to be the most suitable in terms of percutaneous permeation and anti-inflammatory activity due to the greater deformability of these vesicles compared to multidrug ultradeformable vesicles with sodium deoxycholate. Our findings are very encouraging and suggest the use of these carriers in the topical treatment of inflammatory diseases.
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Keywords:
ultradermable vesicles; Tween® 80; sodium deoxycholate; naproxen sodium; idebenone; inflammation; transdermal drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Molinaro, R.; Gagliardi, A.; Mancuso, A.; Cosco, D.; Soliman, M.E.; Casettari, L.; Paolino, D. Development and In Vivo Evaluation of Multidrug Ultradeformable Vesicles for the Treatment of Skin Inflammation. Pharmaceutics 2019, 11, 644.
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