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Open AccessReview

Targeting Persistent Human Papillomavirus Infection

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
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Author to whom correspondence should be addressed.
Academic Editor: Alison A. McBride
Viruses 2017, 9(8), 229; https://doi.org/10.3390/v9080229
Received: 30 July 2017 / Revised: 30 July 2017 / Accepted: 15 August 2017 / Published: 18 August 2017
(This article belongs to the Special Issue Expert Views on HPV Infection)
While the majority of Human papillomavirus (HPV) infections are transient and cleared within a couple of years following exposure, 10–20% of infections persist latently, leading to disease progression and, ultimately, various forms of invasive cancer. Despite the clinical efficiency of recently developed multivalent prophylactic HPV vaccines, these preventive measures are not effective against pre-existing infection. Additionally, considering that the burden associated with HPV is greatest in regions with limited access to preventative vaccination, the development of effective therapies targeting persistent infection remains imperative. This review discusses not only the mechanisms underlying persistent HPV infection, but also the promise of immunomodulatory therapeutic vaccines and small-molecular inhibitors, which aim to augment the host immune response against the viral infection as well as obstruct critical viral–host interactions. View Full-Text
Keywords: HPV; persistent infection; cervical cancer; therapeutics; vaccines; episome maintenance; E2 protein HPV; persistent infection; cervical cancer; therapeutics; vaccines; episome maintenance; E2 protein
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MDPI and ACS Style

Shanmugasundaram, S.; You, J. Targeting Persistent Human Papillomavirus Infection. Viruses 2017, 9, 229.

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