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Viruses 2017, 9(3), 42;

Non-Canonical Roles of Dengue Virus Non-Structural Proteins

Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, CCS, Bl. E, sala 18, Rio de Janeiro 21941-90, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Michael R. Holbrook
Received: 16 December 2016 / Revised: 6 March 2017 / Accepted: 8 March 2017 / Published: 13 March 2017
(This article belongs to the Special Issue Advances in Flavivirus Research)
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The Flaviviridae family comprises a number of human pathogens, which, although sharing structural and functional features, cause diseases with very different outcomes. This can be explained by the plurality of functions exerted by the few proteins coded by viral genomes, with some of these functions shared among members of a same family, but others being unique for each virus species. These non-canonical functions probably have evolved independently and may serve as the base to the development of specific therapies for each of those diseases. Here it is discussed what is currently known about the non-canonical roles of dengue virus (DENV) non-structural proteins (NSPs), which may account for some of the effects specifically observed in DENV infection, but not in other members of the Flaviviridae family. This review explores how DENV NSPs contributes to the physiopathology of dengue, evasion from host immunity, metabolic changes, and redistribution of cellular components during infection. View Full-Text
Keywords: dengue virus; non-structural proteins; physiopathology; immunity; metabolism dengue virus; non-structural proteins; physiopathology; immunity; metabolism

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Zeidler, J.D.; Fernandes-Siqueira, L.O.; Barbosa, G.M.; Da Poian, A.T. Non-Canonical Roles of Dengue Virus Non-Structural Proteins. Viruses 2017, 9, 42.

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