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Open AccessCommentary

The New High Resolution Crystal Structure of NS2B-NS3 Protease of Zika Virus

Department of Chemistry, Islamia College University, Peshawar 25120, Khyber Pukhtoonkhwa, Pakistan
National Center of Excellence in Physical Chemistry, University of Peshawar, Peshawar 25120, Khyber Pukhtoonkhwa, Pakistan
Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Authors to whom correspondence should be addressed.
Academic Editor: Michael Holbrook
Viruses 2017, 9(1), 7;
Received: 19 December 2016 / Accepted: 1 January 2017 / Published: 10 January 2017
(This article belongs to the Special Issue Advances in Flavivirus Research)
PDF [164 KB, uploaded 10 January 2017]


Zika virus (ZIKV) is the cause of a significant viral disease affecting humans, which has spread throughout many South American countries and has also become a threat to Southeastern Asia. This commentary discusses the article “Crystal structure of unlinked NS2B-NS3 protease from Zika virus” published recently in the journal Science by Zhang et al. of Nanyang Technological University, Singapore. They resolved a 1.58 Å resolution structure of the NS2B-NS3 protease of ZIKV and demonstrated how peptide and non-peptide inhibitors interact with this structure, along with the different conformational states that were observed. This protease crystal structure offers new opportunities for the design and development of novel antiviral drugs used for the treatment and control of ZIKV. View Full-Text
Keywords: Zika virus; microcephaly; non-structural protein; protease; inhibitors Zika virus; microcephaly; non-structural protein; protease; inhibitors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Badshah, S.L.; Naeem, A.; Mabkhot, Y. The New High Resolution Crystal Structure of NS2B-NS3 Protease of Zika Virus. Viruses 2017, 9, 7.

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