The Role of HBZ in HTLV-1-Induced Oncogenesis
AbstractHuman T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and chronic inflammatory diseases. HTLV-1 bZIP factor (HBZ) is transcribed as an antisense transcript of the HTLV-1 provirus. Among the HTLV-1-encoded viral genes, HBZ is the only gene that is constitutively expressed in all ATL cases. Recent studies have demonstrated that HBZ plays an essential role in oncogenesis by regulating viral transcription and modulating multiple host factors, as well as cellular signaling pathways, that contribute to the development and continued growth of cancer. In this article, I summarize the current knowledge of the oncogenic function of HBZ in cell proliferation, apoptosis, T-cell differentiation, immune escape, and HTLV-1 pathogenesis. View Full-Text
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Zhao, T. The Role of HBZ in HTLV-1-Induced Oncogenesis. Viruses 2016, 8, 34.
Zhao T. The Role of HBZ in HTLV-1-Induced Oncogenesis. Viruses. 2016; 8(2):34.Chicago/Turabian Style
Zhao, Tiejun. 2016. "The Role of HBZ in HTLV-1-Induced Oncogenesis." Viruses 8, no. 2: 34.
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