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Viruses
Volume 14
Issue 1
10.3390/v14010026
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Article

Vaccination Hesitancy among Health-Care-Workers in Academic Hospitals Is Associated with a 12-Fold Increase in the Risk of COVID-19 Infection: A Nine-Month Greek Cohort Study

by
Fotinie Ntziora
1,*,
Evangelia Georgia Kostaki
2,
Ioannis Grigoropoulos
3,
Amalia Karapanou
1,
Ismini Kliani
3,
Maria Mylona
1,
Alexa Thomollari
3,
Sotirios Tsiodras
3,4,
Theoklis Zaoutis
4,
Dimitrios Paraskevis
2,4,
Nikolaos V. Sipsas
5,
Anastasia Antoniadou
3 and
Petros P. Sfikakis
1
1
1st Department of Propaedeutic Internal Medicine, University General Hospital Laiko, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
2
Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
3
4th Department of Internal Medicine, University General Hospital Attikon, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece
4
National Public Health Organization, 15123 Athens, Greece
5
Pathophysiology Department, University General Hospital Laiko, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editors: Luis Martinez-Sobrido, Stefano Aquaro and Giorgio Palù
Viruses 2022, 14(1), 26; https://doi.org/10.3390/v14010026
Received: 24 November 2021 / Revised: 11 December 2021 / Accepted: 20 December 2021 / Published: 24 December 2021
(This article belongs to the Topic Burden of COVID-19 in Different Countries)
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Abstract

Health-Care-Workers (HCWs) are considered at high risk for SARS-CoV-2 infection. We sought to compare rates and severity of Coronavirus disease 2019 (COVID-19) among vaccinated and unvaccinated HCWs conducting a retrospective cohort study in two tertiary Academic Hospitals, namely Laiko and Attikon, in Athens, Greece. Vaccinated by BNT162b2 Pfizer-BioNTech COVID-19 mRNA vaccine and unvaccinated HCWs were included and data were collected between 1 January 2021 and 15 September 2021. Overall, 2921 of 3219 HCWs without a history of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection were fully vaccinated during the study period (90.7% at each Hospital). Demographic characteristics were comparable between 102/2921 (3.5%) vaccinated and 88/298 (29.5%) unvaccinated HCWs with COVID-19, although age and occupation differed significantly. None were in need of hospital admission in the vaccinated Group, whereas in the unvaccinated Group 4/88 (4.5%) were hospitalized and one (1.1%) died. Multivariable logistic regression analysis revealed that lack of vaccination was an independent risk factor for COVID-19 with an odds ratio 11.54 (95% CI: 10.75–12.40). Vaccination hesitancy among HCWs resulted to highly increased COVID-19 rates; almost one in three unvaccinated HCWs was SARS-CoV-2 infected during the 9-month period. The absolute need of vaccination of HCWs, including boosting dose, is highlighted. Evidence should be used appropriately to overcome any hesitancy. View Full-Text
Keywords: Coronavirus disease 2019 (COVID-19); vaccine; infection rate; hesitancy; Health-Care-Workers (HCWs) Coronavirus disease 2019 (COVID-19); vaccine; infection rate; hesitancy; Health-Care-Workers (HCWs)
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MDPI and ACS Style

Ntziora, F.; Kostaki, E.G.; Grigoropoulos, I.; Karapanou, A.; Kliani, I.; Mylona, M.; Thomollari, A.; Tsiodras, S.; Zaoutis, T.; Paraskevis, D.; Sipsas, N.V.; Antoniadou, A.; Sfikakis, P.P. Vaccination Hesitancy among Health-Care-Workers in Academic Hospitals Is Associated with a 12-Fold Increase in the Risk of COVID-19 Infection: A Nine-Month Greek Cohort Study. Viruses 2022, 14, 26. https://doi.org/10.3390/v14010026

AMA Style

Ntziora F, Kostaki EG, Grigoropoulos I, Karapanou A, Kliani I, Mylona M, Thomollari A, Tsiodras S, Zaoutis T, Paraskevis D, Sipsas NV, Antoniadou A, Sfikakis PP. Vaccination Hesitancy among Health-Care-Workers in Academic Hospitals Is Associated with a 12-Fold Increase in the Risk of COVID-19 Infection: A Nine-Month Greek Cohort Study. Viruses. 2022; 14(1):26. https://doi.org/10.3390/v14010026

Chicago/Turabian Style

Ntziora, Fotinie, Evangelia G. Kostaki, Ioannis Grigoropoulos, Amalia Karapanou, Ismini Kliani, Maria Mylona, Alexa Thomollari, Sotirios Tsiodras, Theoklis Zaoutis, Dimitrios Paraskevis, Nikolaos V. Sipsas, Anastasia Antoniadou, and Petros P. Sfikakis. 2022. "Vaccination Hesitancy among Health-Care-Workers in Academic Hospitals Is Associated with a 12-Fold Increase in the Risk of COVID-19 Infection: A Nine-Month Greek Cohort Study" Viruses 14, no. 1: 26. https://doi.org/10.3390/v14010026

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