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Article

Characterization of Novel Rhabdoviruses in Chinese Bats

1
CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
3
Institut Pasteur, Lyssavirus Epidemiology and Neuropathology Unit, 75724 Paris, France
4
Hunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha 410082, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Christopher Broder
Viruses 2021, 13(1), 64; https://doi.org/10.3390/v13010064
Received: 31 October 2020 / Revised: 24 December 2020 / Accepted: 30 December 2020 / Published: 5 January 2021
(This article belongs to the Special Issue Lyssaviruses and Other Bat Rhabdoviruses)
Bats, the second largest order of mammals worldwide, harbor specific characteristics such as sustaining flight, a special immune system, unique habits, and ecological niches. In addition, they are the natural reservoirs of a variety of emerging or re-emerging zoonotic pathogens. Rhabdoviridae is one of the most diverse families of RNA viruses, which consists of 20 ecologically diverse genera, infecting plants, mammals, birds, reptiles, and fish. To date, three bat-related genera are described, named Lyssavirus, Vesiculovirus, and Ledantevirus. However, the prevalence and the distribution of these bat-related rhabdoviruses remain largely unknown, especially in China. To fill this gap, we performed a large molecular retrospective study based on the real-time reverse transcription polymerase chain reaction (RT-qPCR) detection of lyssavirus in bat samples (1044 brain and 3532 saliva samples, from 63 different bat species) originating from 21 provinces of China during 2006–2018. None of them were positive for lyssavirus, but six bat brains (0.6%) of Rhinolophus bat species, originating from Hubei and Hainan provinces, were positive for vesiculoviruses or ledanteviruses. Based on complete genomes, these viruses were phylogenetically classified into three putative new species, tentatively named Yinshui bat virus (YSBV), Taiyi bat virus (TYBV), and Qiongzhong bat virus (QZBV). These results indicate the novel rhabdoviruses circulated in different Chinese bat populations. View Full-Text
Keywords: bat; rhabdovirus; lyssavirus; vesiculovirus; ledantevirus; China; RT-qPCR; phylogeny; brain; complete genome bat; rhabdovirus; lyssavirus; vesiculovirus; ledantevirus; China; RT-qPCR; phylogeny; brain; complete genome
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MDPI and ACS Style

Luo, D.-S.; Li, B.; Shen, X.-R.; Jiang, R.-D.; Zhu, Y.; Wu, J.; Fan, Y.; Bourhy, H.; Hu, B.; Ge, X.-Y.; Shi, Z.-L.; Dacheux, L. Characterization of Novel Rhabdoviruses in Chinese Bats. Viruses 2021, 13, 64. https://doi.org/10.3390/v13010064

AMA Style

Luo D-S, Li B, Shen X-R, Jiang R-D, Zhu Y, Wu J, Fan Y, Bourhy H, Hu B, Ge X-Y, Shi Z-L, Dacheux L. Characterization of Novel Rhabdoviruses in Chinese Bats. Viruses. 2021; 13(1):64. https://doi.org/10.3390/v13010064

Chicago/Turabian Style

Luo, Dong-Sheng, Bei Li, Xu-Rui Shen, Ren-Di Jiang, Yan Zhu, Jia Wu, Yi Fan, Hervé Bourhy, Ben Hu, Xing-Yi Ge, Zheng-Li Shi, and Laurent Dacheux. 2021. "Characterization of Novel Rhabdoviruses in Chinese Bats" Viruses 13, no. 1: 64. https://doi.org/10.3390/v13010064

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