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Cell-Mediated Responses to Human Metapneumovirus Infection

VIB-UGent Center for Medical Biotechnology, VIB, B-9052 Ghent, Belgium
Department of Biochemistry and Microbiology, Ghent University, B-9000 Ghent, Belgium
Author to whom correspondence should be addressed.
Viruses 2020, 12(5), 542;
Received: 24 March 2020 / Revised: 9 May 2020 / Accepted: 12 May 2020 / Published: 14 May 2020
(This article belongs to the Special Issue From RSV to hMPV: Role of Innate Immunity in Pathogenesis)
Viruses are the most common cause of acute respiratory tract infections (ARTI). Human metapneumovirus (hMPV) frequently causes viral pneumonia which can become life-threatening if the virus spreads to the lungs. Even though hMPV was only isolated in 2001, this negative-stranded RNA virus has probably been circulating in the human population for many decades. Interestingly, almost all adults have serologic evidence of hMPV infection. A well-established host immune response is evoked when hMPV infection occurs. However, the virus has evolved to circumvent and even exploit the host immune response. Further, infection with hMPV induces a weak memory response, and re-infections during life are common. In this review, we provide a comprehensive overview of the different cell types involved in the immune response in order to better understand the immunopathology induced by hMPV. Such knowledge may contribute to the development of vaccines and therapeutics directed against hMPV. View Full-Text
Keywords: human metapneumovirus; innate and adaptive immune response; evasion strategies human metapneumovirus; innate and adaptive immune response; evasion strategies
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Ballegeer, M.; Saelens, X. Cell-Mediated Responses to Human Metapneumovirus Infection. Viruses 2020, 12, 542.

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