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Proteomics Computational Analyses Suggest that the Envelope Glycoproteins of Segmented Jingmen Flavi-Like Viruses Are Class II Viral Fusion Proteins (β-Penetrenes) with Mucin-Like Domains

1
School of Nursing, Johns Hopkins University, Baltimore, MD 21205, USA
2
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA
3
Zalgen Labs, Germantown, MD 20876, USA
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(3), 260; https://doi.org/10.3390/v12030260
Received: 7 February 2020 / Revised: 21 February 2020 / Accepted: 25 February 2020 / Published: 27 February 2020
(This article belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Jingmen viruses are newly described segmented flavi-like viruses that have a worldwide distribution in ticks and have been associated with febrile illnesses in humans. Computational analyses were used to predict that Jingmen flavi-like virus glycoproteins have structural features of class II viral fusion proteins, including an ectodomain consisting of beta-sheets and short alpha-helices, a fusion peptide with interfacial hydrophobicity and a three-domain architecture. Jingmen flavi-like virus glycoproteins have a sequence enriched in serine, threonine, and proline at the amino terminus, which is a feature of mucin-like domains. Several of the serines and threonines are predicted be modified by the addition of O-linked glycans. Some of the glycoproteins are predicted to have an additional mucin-like domain located prior to the transmembrane anchor, whereas others are predicted to have a stem consisting of two alpha-helices. The flavivirus envelope protein and Jingmen flavi-virus glycoproteins may have diverged from a common class II precursor glycoprotein with a mucin-like domain or domains acquired after divergence. View Full-Text
Keywords: Jingmen tick virus; Alongshan virus; flavi-like viruses; class II viral fusion proteins; O-liked glycans; mucin-like domain; virus evolution Jingmen tick virus; Alongshan virus; flavi-like viruses; class II viral fusion proteins; O-liked glycans; mucin-like domain; virus evolution
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MDPI and ACS Style

Garry, C.E.; Garry, R.F. Proteomics Computational Analyses Suggest that the Envelope Glycoproteins of Segmented Jingmen Flavi-Like Viruses Are Class II Viral Fusion Proteins (β-Penetrenes) with Mucin-Like Domains. Viruses 2020, 12, 260. https://doi.org/10.3390/v12030260

AMA Style

Garry CE, Garry RF. Proteomics Computational Analyses Suggest that the Envelope Glycoproteins of Segmented Jingmen Flavi-Like Viruses Are Class II Viral Fusion Proteins (β-Penetrenes) with Mucin-Like Domains. Viruses. 2020; 12(3):260. https://doi.org/10.3390/v12030260

Chicago/Turabian Style

Garry, Courtney E., and Robert F. Garry. 2020. "Proteomics Computational Analyses Suggest that the Envelope Glycoproteins of Segmented Jingmen Flavi-Like Viruses Are Class II Viral Fusion Proteins (β-Penetrenes) with Mucin-Like Domains" Viruses 12, no. 3: 260. https://doi.org/10.3390/v12030260

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