Next Article in Journal
Interplay between Hepatitis D Virus and the Interferon Response
Previous Article in Journal
Fatal Interstitial Pneumonia Associated with Bovine Coronavirus in Cows from Southern Italy
Previous Article in Special Issue
Significance of Viral Activity for Regulating Heterotrophic Prokaryote Community Dynamics along a Meridional Gradient of Stratification in the Northeast Atlantic Ocean
Article

Virome Variation during Sea Star Wasting Disease Progression in Pisaster ochraceus (Asteroidea, Echinodermata)

1
Department of Microbiology, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14850, USA
2
Department of Biology, Estuary and Ocean Science Center, San Francisco State University, Tiburon, CA 94920, USA
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(11), 1332; https://doi.org/10.3390/v12111332
Received: 6 October 2020 / Revised: 8 November 2020 / Accepted: 19 November 2020 / Published: 20 November 2020
(This article belongs to the Special Issue Viruses of Aquatic Ecosystems)
Sea star wasting disease (SSWD) is a condition that has affected asteroids for over 120 years, yet mechanistic understanding of this wasting etiology remains elusive. We investigated temporal virome variation in two Pisaster ochraceus specimens that wasted in the absence of external stimuli and two specimens that did not experience SSWD for the duration of our study, and compared viromes of wasting lesion margin tissues to both artificial scar margins and grossly normal tissues over time. Global assembly of all SSWD-affected tissue libraries resulted in 24 viral genome fragments represented in >1 library. Genome fragments mostly matched densoviruses and picornaviruses with fewer matching nodaviruses, and a sobemovirus. Picornavirus-like and densovirus-like genome fragments were most similar to viral genomes recovered in metagenomic study of other marine invertebrates. Read recruitment revealed only two picornavirus-like genome fragments that recruited from only SSWD-affected specimens, but neither was unique to wasting lesions. Wasting lesion margin reads recruited to a greater number of viral genotypes (i.e., richness) than did either scar tissue and grossly normal tissue reads. Taken together, these data suggest that no single viral genome fragment was associated with SSWD. Rather, wasting lesion margins may generally support viral proliferation. View Full-Text
Keywords: densovirus; picornavirus; nodavirus; sea star wasting disease; asteroidea densovirus; picornavirus; nodavirus; sea star wasting disease; asteroidea
Show Figures

Figure 1

MDPI and ACS Style

Hewson, I.; Aquino, C.A.; DeRito, C.M. Virome Variation during Sea Star Wasting Disease Progression in Pisaster ochraceus (Asteroidea, Echinodermata). Viruses 2020, 12, 1332. https://doi.org/10.3390/v12111332

AMA Style

Hewson I, Aquino CA, DeRito CM. Virome Variation during Sea Star Wasting Disease Progression in Pisaster ochraceus (Asteroidea, Echinodermata). Viruses. 2020; 12(11):1332. https://doi.org/10.3390/v12111332

Chicago/Turabian Style

Hewson, Ian, Citlalli A. Aquino, and Christopher M. DeRito 2020. "Virome Variation during Sea Star Wasting Disease Progression in Pisaster ochraceus (Asteroidea, Echinodermata)" Viruses 12, no. 11: 1332. https://doi.org/10.3390/v12111332

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop