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Article

Fatal Interstitial Pneumonia Associated with Bovine Coronavirus in Cows from Southern Italy

1
Unit of Virology, Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy
2
Section of Vibo Valentia, Experimental Zooprophylactic Institute of Southern Italy, Contrada Piano di Bruno, 89852 Mileto, Italy
3
Department of Animal Health, Experimental Zooprophylactic Institute of Southern Italy, Via Salute 2, 80055 Portici, Italy
4
Freelance Veterinary, Ordine dei Veterinari di Vibo Valentia, 89900 Vibo Valentia, Italy
*
Author to whom correspondence should be addressed.
The two authors equally contributed to the paper.
Viruses 2020, 12(11), 1331; https://doi.org/10.3390/v12111331
Received: 9 October 2020 / Revised: 13 November 2020 / Accepted: 17 November 2020 / Published: 19 November 2020
(This article belongs to the Special Issue Enteric Viruses in Animals)
An outbreak of winter dysentery, complicated by severe respiratory syndrome, occurred in January 2020 in a high production dairy cow herd located in a hilly area of the Calabria region. Of the 52 animals belonging to the farm, 5 (9.6%) died with severe respiratory distress, death occurring 3–4 days after the appearance of the respiratory signs (caught and gasping breath). Microbiological analysis revealed absence of pathogenic bacteria whilst Real-time PCR identified the presence of RNA from Bovine Coronavirus (BCoV) in several organs: lungs, small intestine (jejunum), mediastinal lymph nodes, liver and placenta. BCoV was therefore hypothesized to play a role in the lethal pulmonary infection. Like the other CoVs, BCoV is able to cause different syndromes. Its role in calf diarrhea and in mild respiratory disease is well known: we report instead the involvement of this virus in a severe and fatal respiratory disorder, with symptoms and disease evolution resembling those of Severe Acute Respiratory Syndromes (SARS). View Full-Text
Keywords: bovine coronavirus; interstitial pneumonia; phylogenetic analysis; real time PCR bovine coronavirus; interstitial pneumonia; phylogenetic analysis; real time PCR
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MDPI and ACS Style

Amoroso, M.G.; Lucifora, G.; Degli Uberti, B.; Serra, F.; De Luca, G.; Borriello, G.; De Domenico, A.; Brandi, S.; Cuomo, M.C.; Bove, F.; Riccardi, M.G.; Galiero, G.; Fusco, G. Fatal Interstitial Pneumonia Associated with Bovine Coronavirus in Cows from Southern Italy. Viruses 2020, 12, 1331. https://doi.org/10.3390/v12111331

AMA Style

Amoroso MG, Lucifora G, Degli Uberti B, Serra F, De Luca G, Borriello G, De Domenico A, Brandi S, Cuomo MC, Bove F, Riccardi MG, Galiero G, Fusco G. Fatal Interstitial Pneumonia Associated with Bovine Coronavirus in Cows from Southern Italy. Viruses. 2020; 12(11):1331. https://doi.org/10.3390/v12111331

Chicago/Turabian Style

Amoroso, Maria G., Giuseppe Lucifora, Barbara Degli Uberti, Francesco Serra, Giovanna De Luca, Giorgia Borriello, Alessandro De Domenico, Sergio Brandi, Maria C. Cuomo, Francesca Bove, Marita G. Riccardi, Giorgio Galiero, and Giovanna Fusco. 2020. "Fatal Interstitial Pneumonia Associated with Bovine Coronavirus in Cows from Southern Italy" Viruses 12, no. 11: 1331. https://doi.org/10.3390/v12111331

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