Next Article in Journal
Curcumin as an Antiviral Agent
Next Article in Special Issue
Low Aedes aegypti Vector Competence for Zika Virus from Viremic Rhesus Macaques
Previous Article in Journal
HCV Genetic Diversity Can Be Used to Infer Infection Recency and Time since Infection
Previous Article in Special Issue
Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis

TBEV Subtyping in Terms of Genetic Distance

Laboratory of Molecular Biology and Biochemistry, Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119048 Moscow, Russia
Department of Organization and Technology of Immunobiological Preparations, Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 119991 Moscow, Russia
Laboratory of Biology of Arboviruses, Chumakov Institute of Poliomyelitis and Viral Encephalitides (FSBSI “Chumakov FSC R&D IBP RAS), 108819 Moscow, Russia
Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov First Moscow State Medical University, 119435 Moscow, Russia
Department of Virology, Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia
Author to whom correspondence should be addressed.
Viruses 2020, 12(11), 1240;
Received: 10 October 2020 / Revised: 24 October 2020 / Accepted: 29 October 2020 / Published: 31 October 2020
(This article belongs to the Special Issue Emerging Arboviruses)
Currently, the lowest formal taxon in virus classification is species; however, unofficial lower-level units are commonly used in everyday work. Tick-borne encephalitis virus (TBEV) is a species of mammalian tick-borne flaviviruses that may cause encephalitis. Many known representatives of TBEV are grouped into subtypes, mostly according to their phylogenetic relationship. However, the emergence of novel sequences could dissolve this phylogenetic grouping; in the absence of strict quantitative criterion, it may be hard to define the borders of the first TBEV taxonomic unit below the species level. In this study, the nucleotide/amino-acid space of all known TBEV sequences was analyzed. Amino-acid sequence p-distances could not reliably distinguish TBEV subtypes. Viruses that differed by less than 10% of nucleotides in the polyprotein-coding gene belonged to the same subtype. At the same time, more divergent viruses were representatives of different subtypes. According to this distance criterion, TBEV species may be divided into seven subtypes: TBEV-Eur, TBEV-Sib, TBEV-FE, TBEV-2871 (TBEV-Ob), TBEV-Him, TBEV-178-79 (TBEV-Bkl-1), and TBEV-886-84 (TBEV-Bkl-2). View Full-Text
Keywords: TBEV; taxonomy; subtypes; pairwise genetic distance TBEV; taxonomy; subtypes; pairwise genetic distance
Show Figures

Figure 1

MDPI and ACS Style

Deviatkin, A.A.; Karganova, G.G.; Vakulenko, Y.A.; Lukashev, A.N. TBEV Subtyping in Terms of Genetic Distance. Viruses 2020, 12, 1240.

AMA Style

Deviatkin AA, Karganova GG, Vakulenko YA, Lukashev AN. TBEV Subtyping in Terms of Genetic Distance. Viruses. 2020; 12(11):1240.

Chicago/Turabian Style

Deviatkin, Andrei A., Galina G. Karganova, Yulia A. Vakulenko, and Alexander N. Lukashev. 2020. "TBEV Subtyping in Terms of Genetic Distance" Viruses 12, no. 11: 1240.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop