Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Strategy and Selection
2.2. Data Analysis
3. Results
3.1. Regional Distribution of Records Reporting ZIKV with Joint Signs/Symptoms
3.2. Outbreaks of ZIKV with Joint Signs/Symptoms
3.3. Case Studies Reporting Confirmed ZIKV Cases with Joint Signs/Symptoms
3.3.1. Arthralgia and Joint/Articular Pain
3.3.2. Arthritis
3.4. Population-Based Studies Reporting Confirmed ZIKV Cases with Joint Signs/Symptoms
3.4.1. Meta-Analysis for Pooled Prevalence of Joint Signs/Symptoms
3.4.2. Prevalence of Joint Signs/Symptoms during ZIKV Outbreaks Depends on the Geographic Location
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Included | Excluded | |
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Report type | Abstracts and full-length articles, conference proceedings, case reports, letters, brief reports, short communications, correspondence and editorials with novel data. English abstracts of full papers published in other languages were too included. | Opinions, letters, editorials and correspondence without new data; similar data or findings published under different titles or in different formats; review articles, book chapters, animal research or perspectives without new data. |
Study design | Any randomised or non-randomised design. | Modelled data, review data. |
Results Place and time of occurrence | Symptomatic ZIKV incidence in any human population during any time interval. | |
Type of the occurrence | Imported cases, sporadic cases, case series or disease clusters; outbreaks and epidemics case reports. | |
Person (number of cases, age and sex) of affected people | Only laboratory-confirmed human cases. | Laboratory-confirmed cases of co-infection of ZIKV with other diseases/infections (e.g. Dengue and Chikungunya) Missing or unclear laboratory-based method; suspected/probable ZIKV cases. |
Meta-analysis | Articles describing epidemiological features of ZIKV outbreaks. Comparison of prevalence of arthralgia and arthritis in the studies that gave information about both manifestations separately in the same study. | Purposes other than epidemiological evaluation of ZIKV or restricted to defined population. |
PubMed Search | Scopus Search |
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Search: ((((((arthralgia) OR (“joint pain”)) OR (rheumatology)) OR (“joint swelling”)) OR (“inflammatory joint pain”)) OR (arthritis)) AND (zika) Sort by: Most Recent (((((((“arthralgia”[MeSH Terms] OR “arthralgia”[All Fields]) OR “arthralgias”[All Fields]) OR “joint pain”[All Fields]) OR ((“rheumatology”[MeSH Terms] OR “rheumatology”[All Fields]) OR “rheumatology s”[All Fields])) OR “joint swelling”[All Fields]) OR “inflammatory joint pain”[All Fields]) OR (((“arthritis”[MeSH Terms] OR “arthritis”[All Fields]) OR “arthritides”[All Fields]) OR “polyarthritides”[All Fields])) AND ((((((“zika virus”[MeSH Terms] OR (“zika”[All Fields] AND “virus”[All Fields])) OR “zika virus”[All Fields]) OR “zika”[All Fields]) OR “zika virus infection”[MeSH Terms]) OR ((“zika”[All Fields] AND “virus”[All Fields]) AND “infection”[All Fields])) OR “zika virus infection”[All Fields]) Translations arthralgia: “arthralgia”[MeSH Terms] OR “arthralgia”[All Fields] OR “arthralgias”[All Fields] rheumatology: “rheumatology”[MeSH Terms] OR “rheumatology”[All Fields] OR “rheumatology’s”[All Fields] arthritis: “arthritis”[MeSH Terms] OR “arthritis”[All Fields] OR “arthritides”[All Fields] OR “polyarthritides”[All Fields] zika: “zika virus”[MeSH Terms] OR (“zika”[All Fields] AND “virus”[All Fields]) OR “zika virus”[All Fields] OR “zika”[All Fields] OR “zika virus infection”[MeSH Terms] OR (“zika”[All Fields] AND “virus”[All Fields] AND “infection”[All Fields]) OR “zika virus infection”[All Fields] | TITLE-ABS-KEY (arthralgia OR arthritis OR “joint pain” OR rheumatology OR “joint swelling” OR “inflammatory joint pain” AND zika) |
Region | Number of Articles | Countries Reporting Confirmed ZIKV Cases with Joint Symptoms |
---|---|---|
African Region | 1 | Ghana |
Region of the Americas | 96 | Brazil, Canada, Colombia, Cuba, Dominican Republic, French Guiana, Honduras, Martinique, Mexico, Nicaragua, Panama, Peru, Puerto Rico, Suriname, Trinidad and Tobago, United States, Venezuela |
European Region | 27 | Belgium, Croatia, France, Germany, Italy, Netherlands, Norway, Portugal, Russia, Spain, Switzerland, Turkey, United Kingdom |
Eastern Mediterranean Region | 0 | |
Western Pacific Region | 5 | French Polynesia, Micronesia, New Caledonia, New Zealand |
South-East Asia Region | 8 | Indonesia, Japan, Korea, Singapore, Viet Nam Thailand |
Authors | Sign/Symptom | Reporter | Duration (Days) | Number of Cases | Joint(s) Affected | Country of Report | Age (Years) | Sex | Comorbidities | Diagnosed by | Source |
---|---|---|---|---|---|---|---|---|---|---|---|
Bachiller-Luque et al., 2016 | Arthralgia and synovitis | Clinician | 5 | 1 | Fingers, right knee, ankle and elbow | Spain | 49 | Male | Irritable bowel syndrome, hypertension, dyslipidemia | RT-PCR | Imported |
Penot et al., 2017 | Arthritis, joints pain and swelling | Clinician | >10 (all cases) | 3 | Case 2—ankles and phalanges. Case 3—bilateral and symmetrical wrists, ankles and phalanges. Case 4—bilateral knees | France | 36, 30, 39 | All are female | Patient 3- Previously healthy Patient 4- hypothyroidism and non-treated rheumatoid polyarthritis | RT-PCR | Imported |
Fabrizius et al., 2016 | Effusion with tenderness to palpation | Clinician | 1 | Finger joints | United States | 44 | Male | Previously healthy | RT-PCR | Imported | |
Kulkarni et al., 2016 | Mild synovitis | Clinician | 1 | Metacarpophalangeal and proximal interphalangeal joints bilaterally | United States | 42 | Female | Previously healthy | IgM and Zika virus PRNT | Imported | |
Rozé et al., 2016 | Peripheral arthritis | Clinician | 1 | Peripheral arthritis | Martinique | Late 70s | Not given | RT-PCR | Local | ||
Nicastri et al., 2016 | Bilateral wrists swelling | Clinician | 1 | Bilateral wrists | Italy | 74 | Male | RT-PCR, serology, neutralisation | Imported | ||
Zammarchi et al., 2015 | Arthralgia and ankle oedema | Patient | 2 | Ankle | Italy | Early30s | Male & Female | RT-PCR/ IgG/IgM | Imported | ||
Harrower et al., 2016 | Arthralgia and ankle oedema | Patient | 1 | Ankle | New Zealand | 51 | Male | RT-PCR | Imported | ||
Arsuaga et al., 2016 | Arthritis | Patient | 7, 8 | 2 | Ankles and wrists | Spain | 53, 51 | Male & Female | RT-PCR | Imported | |
Cavalcanti et al., 2017 | Articular edema | Patient | 1 | Fingers and toes | Brazil | 42 | Female | RT-PCR | Local | ||
Vinhaes et al., 2017 | Oedema in wrists | Patient | 2 | 1 | Wrists | Brazil | 23 | Male | IgM, PRNT | Local | |
Zonneveld et al., 2016 | Arthritis | Patient | 1 | Not given | Suriname | 61 | Male | Hypertension | RT-PCR | Local | |
Díaz-Quiñonez et al., 2016 | Arthritis | Patient | 1 | Not given | Mexico | 26 | Male | RT-PCR | Imported |
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Share and Cite
Wimalasiri-Yapa, B.M.C.R.; Yapa, H.E.; Huang, X.; Hafner, L.M.; Kenna, T.J.; Frentiu, F.D. Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis. Viruses 2020, 12, 1137. https://doi.org/10.3390/v12101137
Wimalasiri-Yapa BMCR, Yapa HE, Huang X, Hafner LM, Kenna TJ, Frentiu FD. Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis. Viruses. 2020; 12(10):1137. https://doi.org/10.3390/v12101137
Chicago/Turabian StyleWimalasiri-Yapa, B.M.C.R., Harith E. Yapa, Xiaodong Huang, Louise M. Hafner, Tony J. Kenna, and Francesca D. Frentiu. 2020. "Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis" Viruses 12, no. 10: 1137. https://doi.org/10.3390/v12101137