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Case Report

Rapid Resolution of Non-Effusive Feline Infectious Peritonitis Uveitis with an Oral Adenosine Nucleoside Analogue and Feline Interferon Omega

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Feline Infectious Peritonitis and Coronavirus Website, 64470 Etchebar, Pyrenees, France
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Independent Researcher, Maidstone ME14 5BF, Kent, UK
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School of Veterinary Medicine, University of Glasgow, Garscube Campus, Bearsden Road, Glasgow G61 1QH, UK
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Newnham Court Veterinary Hospital, Bearsted Road, Weavering, Maidstone ME14 5E, Kent, UK
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(11), 1216; https://doi.org/10.3390/v12111216
Received: 29 August 2020 / Revised: 3 October 2020 / Accepted: 5 October 2020 / Published: 27 October 2020
(This article belongs to the Special Issue Enteric Viruses in Animals)
This is the first report of a successful treatment of a non-effusive feline infectious peritonitis (FIP) uveitis case using an oral adenosine nucleoside analogue drug and feline interferon omega, and alpha-1 acid glycoprotein (AGP) as an indicator of recovery. A 2-year-old male neutered Norwegian Forest Cat presented with uveitis, keratic precipitates, mesenteric lymphadenopathy and weight loss. The cat was hypergammaglobulinaemic and had a non-regenerative anaemia. Feline coronavirus (FCoV) RNA was detected in a mesenteric lymph node fine-needle aspirate by a reverse-transcriptase polymerase chain reaction—non-effusive FIP was diagnosed. Prednisolone acetate eye drops were administered three times daily for 2 weeks. Oral adenosine nucleoside analogue (Mutian) treatment started. Within 50 days of Mutian treatment, the cat had gained over one kilogram in weight, his globulin level reduced from 77 to 51 g/L and his haematocrit increased from 22 to 35%; his uveitis resolved and his sight improved. Serum AGP level reduced from 3100 to 400 μg/mL (within normal limits). Symmetric dimethylarginine (SDMA) was above normal at 28 μg/dL, reducing to 14 μg/dL on the cessation of treatment; whether the SDMA increase was due to FIP lesions in the kidney or Mutian is unknown. Mutian treatment stopped and low-dose oral recombinant feline interferon omega begun—the cat’s recovery continued. View Full-Text
Keywords: feline infectious peritonitis; coronavirus; uveitis; Mutian; adenosine nucleoside analogue; feline interferon omega; mesenteric lymph node; alpha-1 acid glycoprotein; symmetric dimethylarginine feline infectious peritonitis; coronavirus; uveitis; Mutian; adenosine nucleoside analogue; feline interferon omega; mesenteric lymph node; alpha-1 acid glycoprotein; symmetric dimethylarginine
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MDPI and ACS Style

Addie, D.D.; Covell-Ritchie, J.; Jarrett, O.; Fosbery, M. Rapid Resolution of Non-Effusive Feline Infectious Peritonitis Uveitis with an Oral Adenosine Nucleoside Analogue and Feline Interferon Omega. Viruses 2020, 12, 1216. https://doi.org/10.3390/v12111216

AMA Style

Addie DD, Covell-Ritchie J, Jarrett O, Fosbery M. Rapid Resolution of Non-Effusive Feline Infectious Peritonitis Uveitis with an Oral Adenosine Nucleoside Analogue and Feline Interferon Omega. Viruses. 2020; 12(11):1216. https://doi.org/10.3390/v12111216

Chicago/Turabian Style

Addie, Diane D., Johanna Covell-Ritchie, Oswald Jarrett, and Mark Fosbery. 2020. "Rapid Resolution of Non-Effusive Feline Infectious Peritonitis Uveitis with an Oral Adenosine Nucleoside Analogue and Feline Interferon Omega" Viruses 12, no. 11: 1216. https://doi.org/10.3390/v12111216

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