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Mouse APOBEC3 Restriction of Retroviruses

Department of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, 835 S. Wolcott Avenue, Chicago, IL 60612, USA
Author to whom correspondence should be addressed.
Viruses 2020, 12(11), 1217;
Received: 6 October 2020 / Revised: 21 October 2020 / Accepted: 22 October 2020 / Published: 27 October 2020
(This article belongs to the Special Issue APOBECs and Virus Restriction)
Apolipoprotein B mRNA editing enzyme, catalytic peptide 3 (APOBEC3) proteins are critical host proteins that counteract and prevent the replication of retroviruses. Unlike the genome of humans and other species, the mouse genome encodes a single Apobec3 gene, which has undergone positive selection, as reflected by the allelic variants found in different inbred mouse strains. This positive selection was likely due to infection by various mouse retroviruses, which have persisted in their hosts for millions of years. While mouse retroviruses are inhibited by APOBEC3, they nonetheless still remain infectious, likely due to the actions of different viral proteins that counteract this host factor. The study of viruses in their natural hosts provides important insight into their co-evolution. View Full-Text
Keywords: APOBEC3; restriction factor; cytidine deaminase; murine leukemia virus; mouse mammary tumor virus APOBEC3; restriction factor; cytidine deaminase; murine leukemia virus; mouse mammary tumor virus
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MDPI and ACS Style

Salas-Briceno, K.; Zhao, W.; Ross, S.R. Mouse APOBEC3 Restriction of Retroviruses. Viruses 2020, 12, 1217.

AMA Style

Salas-Briceno K, Zhao W, Ross SR. Mouse APOBEC3 Restriction of Retroviruses. Viruses. 2020; 12(11):1217.

Chicago/Turabian Style

Salas-Briceno, Karen, Wenming Zhao, and Susan R. Ross. 2020. "Mouse APOBEC3 Restriction of Retroviruses" Viruses 12, no. 11: 1217.

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