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The RNA-Dependent RNA Polymerase NIb of Potyviruses Plays Multifunctional, Contrasting Roles during Viral Infection

by 1,*,†, 2,†, 3,4 and 3,*
1
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture & Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
2
College of Plant Protection, Henan Agricultural University, Zhengzhou 450002, China
3
London Research and Development Centre, Agriculture and Agri-Food Canada, 1391 Sandford ST, London, ON N5V 4T3, Canada
4
Department of Biology, University of Western Ontario, 1151 Richmond ST N., London, ON N6A 5B7, Canada
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2020, 12(1), 77; https://doi.org/10.3390/v12010077
Received: 29 November 2019 / Revised: 28 December 2019 / Accepted: 3 January 2020 / Published: 8 January 2020
(This article belongs to the Special Issue The Complexity of the Potyviral Interaction Network)
Potyviruses represent the largest group of known plant RNA viruses and include many agriculturally important viruses, such as Plum pox virus, Soybean mosaic virus, Turnip mosaic virus, and Potato virus Y. Potyviruses adopt polyprotein processing as their genome expression strategy. Among the 11 known viral proteins, the nuclear inclusion protein b (NIb) is the RNA-dependent RNA polymerase responsible for viral genome replication. Beyond its principal role as an RNA replicase, NIb has been shown to play key roles in diverse virus–host interactions. NIb recruits several host proteins into the viral replication complexes (VRCs), which are essential for the formation of functional VRCs for virus multiplication, and interacts with the sumoylation pathway proteins to suppress NPR1-mediated immunity response. On the other hand, NIb serves as a target of selective autophagy as well as an elicitor of effector-triggered immunity, resulting in attenuated virus infection. These contrasting roles of NIb provide an excellent example of the complex co-evolutionary arms race between plant hosts and potyviruses. This review highlights the current knowledge about the multifunctional roles of NIb in potyvirus infection, and discusses future research directions. View Full-Text
Keywords: Potyvirus; NIb; RNA-dependent RNA polymerase; virus-host interaction; autophagy; sumoylation; NPR1 Potyvirus; NIb; RNA-dependent RNA polymerase; virus-host interaction; autophagy; sumoylation; NPR1
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MDPI and ACS Style

Shen, W.; Shi, Y.; Dai, Z.; Wang, A. The RNA-Dependent RNA Polymerase NIb of Potyviruses Plays Multifunctional, Contrasting Roles during Viral Infection. Viruses 2020, 12, 77. https://doi.org/10.3390/v12010077

AMA Style

Shen W, Shi Y, Dai Z, Wang A. The RNA-Dependent RNA Polymerase NIb of Potyviruses Plays Multifunctional, Contrasting Roles during Viral Infection. Viruses. 2020; 12(1):77. https://doi.org/10.3390/v12010077

Chicago/Turabian Style

Shen, Wentao; Shi, Yan; Dai, Zhaoji; Wang, Aiming. 2020. "The RNA-Dependent RNA Polymerase NIb of Potyviruses Plays Multifunctional, Contrasting Roles during Viral Infection" Viruses 12, no. 1: 77. https://doi.org/10.3390/v12010077

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