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Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process

1
One Health Research Group, Faculty of Health Sciences, Universidad de las Américas, Quito EC170125, Pichincha, Ecuador
2
Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, France
3
Institut Pasteur, Biology of Enteric Viruses Unit, 75015 Paris, France
4
INSERM U994, Institut National de la Santé et de la Recherche Médicale, 75015 Paris, France
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(9), 859; https://doi.org/10.3390/v11090859
Received: 6 August 2019 / Revised: 5 September 2019 / Accepted: 6 September 2019 / Published: 14 September 2019
(This article belongs to the Special Issue Human Picornaviruses)
RNA recombination is a major driving force in the evolution and genetic architecture shaping of enteroviruses. In particular, intertypic recombination is implicated in the emergence of most pathogenic circulating vaccine-derived polioviruses, which have caused numerous outbreaks of paralytic poliomyelitis worldwide. Recent experimental studies that relied on recombination cellular systems mimicking natural genetic exchanges between enteroviruses provided new insights into the molecular mechanisms of enterovirus recombination and enabled to define a new model of genetic plasticity for enteroviruses. Homologous intertypic recombinant enteroviruses that were observed in nature would be the final products of a multi-step process, during which precursor nonhomologous recombinant genomes are generated through an initial inter-genomic RNA recombination event and can then evolve into a diversity of fitter homologous recombinant genomes over subsequent intra-genomic rearrangements. Moreover, these experimental studies demonstrated that the enterovirus genome could be defined as a combination of genomic modules that can be preferentially exchanged through recombination, and enabled defining the boundaries of these recombination modules. These results provided the first experimental evidence supporting the theoretical model of enterovirus modular evolution previously elaborated from phylogenetic studies of circulating enterovirus strains. This review summarizes our current knowledge regarding the mechanisms of recombination in enteroviruses and presents a new evolutionary process that may apply to other RNA viruses. View Full-Text
Keywords: RNA virus; recombination; emergence; enterovirus; viral evolution RNA virus; recombination; emergence; enterovirus; viral evolution
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MDPI and ACS Style

Muslin, C.; Mac Kain, A.; Bessaud, M.; Blondel, B.; Delpeyroux, F. Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process. Viruses 2019, 11, 859.

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