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Open AccessArticle

Aichi Virus Induces Antiviral Host Defense in Primary Murine Intestinal Epithelial Cells

1
Department of Emergency Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan
2
Department of Physical Therapy, Shu-Zen Junior College of Medicine and Management, Kaohsiung 81362, Taiwan
3
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan
4
Department of Critical Care Center Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan
5
Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan
6
Department of Internal Medicine, National Yang-Ming University, Taipei 12221, Taiwan
7
Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei 11490, Taiwan
*
Author to whom correspondence should be addressed.
Contributed equally.
Viruses 2019, 11(8), 763; https://doi.org/10.3390/v11080763
Received: 29 July 2019 / Revised: 9 August 2019 / Accepted: 15 August 2019 / Published: 19 August 2019
(This article belongs to the Special Issue Human Picornaviruses)
The picornavirus Aichi virus (AiV) is a non-enveloped RNA virus that causes acute gastroenteritis symptoms, such as diarrhea, abdominal pain, nausea, vomiting, and fever. Antiviral host defense involves the fast response of type I interferon (IFN) and the secretion of inflammatory cytokines against pathogens. However, the intestinal inflammatory and antiviral response to AiV infection is poorly understood. This study evaluated the antiviral activity of intestinal epithelial cells (IECs), which form a single-cell layer separating the bowel wall from pathogens. Isolated primary mouse IECs were subjected to AiV infection and virion production, inducing the mRNA expression of type I/type III IFNs and inflammatory cytokines. The mechanism involved induced the expression of phospho-IFN regulatory factor 3 and mitochondrial antiviral-signaling protein of type I IFN signaling. These findings were also observed in AiV-infected human colon carcinoma cells. In summary, a viral productive and pathogenic infection of AiV in primary murine IECs is validated. View Full-Text
Keywords: Aichi virus; intestinal epithelial cells; interferon; IRF3 Aichi virus; intestinal epithelial cells; interferon; IRF3
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MDPI and ACS Style

Chang, Y.-T.; Kung, M.-H.; Hsu, T.-H.; Hung, W.-T.; Chen, Y.-S.; Yen, L.-C.; Chang, T.-H. Aichi Virus Induces Antiviral Host Defense in Primary Murine Intestinal Epithelial Cells. Viruses 2019, 11, 763.

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