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Article

Increased Coffee Intake Reduces Circulating HBV DNA and HBsAg Levels in HBeAg-Negative Infection: A Cohort Study

1
Department of Medical Sciences (DMS), School of Healthcare and Medical Sciences (SHMS), Sunway University, Bandar Sunway, Selangor Darul Ehsan 47500, Malaysia
2
Department of Pre-Clinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Bandar Sungai Long, Selangor 43000, Malaysia
3
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
4
Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(9), 808; https://doi.org/10.3390/v11090808
Received: 18 June 2019 / Revised: 1 August 2019 / Accepted: 3 August 2019 / Published: 1 September 2019
(This article belongs to the Section Animal Viruses)
Coffee is hepatoprotective and potentially antiviral; however, its anti-hepatitis B virus (anti-HBV) property is not known in humans. This study investigated the influence of coffee drinking behaviour as well as clinical and biochemical profiles of hepatitis B e antigen (HBeAg) negative participants on circulating HBV DNA and hepatitis B surface antigen (HBsAg) levels at a 24-week interval. Exactly 114 chronically HBV-infected adult participants were enrolled from the University of Malaya Medical Centre (UMMC), Malaysia. A significant reduction of HBV DNA level was observed in those drinking three or more cups of coffee per day, with a median reduction of 523 IU/mL (P = 0.003). Reduction of HBsAg level was observed in those drinking two cups per day, with a median reduction of 37 IU/mL (P < 0.001). Multivariate analysis showed that increased coffee intake (P = 0.015) and lower ALT level (P = 0.033) were the significant predictors for a lower HBV DNA level, whereas increased coffee intake (P = 0.002) and having a family history of HBV infection (P = 0.021) were the significant predictors for a lower HBsAg level. These data suggest that drinking three cups or more coffee per day reduces circulating HBV DNA and HBsAg levels. View Full-Text
Keywords: hepatitis B virus; coffee; viral load; surface antigen; antiviral hepatitis B virus; coffee; viral load; surface antigen; antiviral
MDPI and ACS Style

Chook, J.B.; Ngeow, Y.F.; Tee, K.K.; Lee, J.W.T.; Mohamed, R. Increased Coffee Intake Reduces Circulating HBV DNA and HBsAg Levels in HBeAg-Negative Infection: A Cohort Study. Viruses 2019, 11, 808. https://doi.org/10.3390/v11090808

AMA Style

Chook JB, Ngeow YF, Tee KK, Lee JWT, Mohamed R. Increased Coffee Intake Reduces Circulating HBV DNA and HBsAg Levels in HBeAg-Negative Infection: A Cohort Study. Viruses. 2019; 11(9):808. https://doi.org/10.3390/v11090808

Chicago/Turabian Style

Chook, Jack B., Yun F. Ngeow, Kok K. Tee, Jamie W.T. Lee, and Rosmawati Mohamed. 2019. "Increased Coffee Intake Reduces Circulating HBV DNA and HBsAg Levels in HBeAg-Negative Infection: A Cohort Study" Viruses 11, no. 9: 808. https://doi.org/10.3390/v11090808

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