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Open AccessArticle

Antibody Response to Feline Calicivirus Vaccination in Healthy Adult Cats

Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany
Institute of Animal Hygiene and Veterinary Public Health, University of Leipzig, 04103 Leipzig, Germany
Author to whom correspondence should be addressed.
Viruses 2019, 11(8), 702;
Received: 22 July 2019 / Accepted: 29 July 2019 / Published: 31 July 2019
(This article belongs to the Special Issue Feline Viruses and Viral Diseases)
PDF [600 KB, uploaded 6 August 2019]


This study evaluated the prevalence of feline calicivirus (FCV) antibodies and response to vaccination in healthy adult cats. Cats >1 year (n = 111) that had not been vaccinated within 12 months of enrollment in the study received a vaccine containing inactivated FCV antigen strains 431 and G1. Antibodies were determined on Days 0, 7, and 28 by virus neutralization (VN) using FCV isolate KS20, and by broad spectrum blocking FCV enzyme-linked immunosorbent assay (ELISA). Factors associated with the presence of antibodies and vaccine response were determined by uni- and multivariate analysis. Pre-vaccination antibodies were detected in 62.2% of cats (CI95%: 52.9–70.1) by VN and in 77.2% (CI95%: 67.5–84.6) by ELISA. A ≥4-fold titer increase after vaccination was observed in 13.6% (CI95%: 8.3–21.4) of cats with VN and 33.7% (CI95%: 24.5–44.5) with ELISA. Factors associated with the presence of pre-vaccination VN antibodies were age (≥2 years; OR: 7.091; p = 0.022) and lack of previous vaccination (OR: 3.472; p = 0.014). The presence of pre-vaccination ELISA antibodies was associated with time since last vaccination (OR: 5.672; p = 0.043). Outdoor cats were more likely to have a ≥4-fold ELISA titer increase (OR: 5.556; p = 0.005). Many cats had pre-vaccination FCV antibodies, and their presence depended on previous vaccinations and increases with age. A ≥4-fold titer increase was rarely observed and was influenced by the lifestyle of the cat. View Full-Text
Keywords: FCV; protection; immunization; antibody titer FCV; protection; immunization; antibody titer

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Bergmann, M.; Speck, S.; Rieger, A.; Truyen, U.; Hartmann, K. Antibody Response to Feline Calicivirus Vaccination in Healthy Adult Cats. Viruses 2019, 11, 702.

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