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Open AccessArticle

Evidence for West Nile Virus and Usutu Virus Infections in Wild and Resident Birds in Germany, 2017 and 2018

1
Friedrich-Loeffler Insitut (FLI), Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Südufer 10, D-17493 Greifswald-Insel Riems, Germany
2
German Centre for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel, 17493 Greifswald-Insel Riems, Germany
3
Institute of Virology (Faculty of veterinary medicine), Leipzig University, An den Tierkliniken 29, D-04103 Leipzig, Germany
4
Clinic for Birds, Reptiles, Amphibians and Fish, Justus Liebig University Giessen, Frankfurter Straße 91, D-35392 Giessen, Germany
5
Clinic for Small Mammals, Reptiles and Birds, University of Veterinary Medicine Hannover, Foundation, Bünteweg 9, D-30559 Hannover, Germany
6
Clinic for Birds and Reptiles (Faculty of veterinary medicine), Leipzig University, An den Tierkliniken 17, D-04103 Leipzig, Germany
7
Seehundstation Nationalpark-Haus Norden-Norddeich, Dörper Weg 24, D-26506 Norden, Germany
8
Clinic for Birds, Small Mammals, Reptiles and Ornamental Fish, Centre for Clinical Veterinary Medicine, Ludwig Maximilians University Munich, Sonnenstraße 18, D-85764 Oberschleißheim, Germany
9
Birds of Prey Rehab Center Rhineland (Greifvogelhilfe Rheinland)/Tierarztpraxis Sudhoff, Hehnerholt 105, D-41069 Mönchengladbach, Germany
10
Department of Veterinary Medicine, Small Animal Clinic, Freie Universität Berlin, Oertzenweg 19 b, D-14163 Berlin, Germany
11
Wildpark Schwarze Berge GmbH & Co. KG, Am Wildpark 1, D-21224 Rosengarten, Germany
12
Tiermedizin am Rothenbaum, Rothenbaumchaussee 195, D-20149 Hamburg, Germany
13
Bernhard-Nocht-Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Bernhardt-Nocht Straße 74, D-20359 Hamburg, Germany
14
Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Institute of Epidemiology, Südufer 10, D-17493 Greifswald-Insel Riems, Germany
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(7), 674; https://doi.org/10.3390/v11070674
Received: 27 June 2019 / Revised: 18 July 2019 / Accepted: 19 July 2019 / Published: 23 July 2019
(This article belongs to the Special Issue West Nile Virus 2019)
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PDF [2411 KB, uploaded 25 July 2019]
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Abstract

Wild birds play an important role as reservoir hosts and vectors for zoonotic arboviruses and foster their spread. Usutu virus (USUV) has been circulating endemically in Germany since 2011, while West Nile virus (WNV) was first diagnosed in several bird species and horses in 2018. In 2017 and 2018, we screened 1709 live wild and zoo birds with real-time polymerase chain reaction and serological assays. Moreover, organ samples from bird carcasses submitted in 2017 were investigated. Overall, 57 blood samples of the live birds (2017 and 2018), and 100 organ samples of dead birds (2017) were positive for USUV-RNA, while no WNV-RNA-positive sample was found. Phylogenetic analysis revealed the first detection of USUV lineage Europe 2 in Germany and the spread of USUV lineages Europe 3 and Africa 3 towards Northern Germany. USUV antibody prevalence rates were high in Eastern Germany in both years. On the contrary, in Northern Germany, high seroprevalence rates were first detected in 2018, with the first emergence of USUV in this region. Interestingly, high WNV-specific neutralizing antibody titers were observed in resident and short-distance migratory birds in Eastern Germany in 2018, indicating the first signs of a local WNV circulation. View Full-Text
Keywords: wild bird; West Nile virus; Usutu virus; Germany; monitoring wild bird; West Nile virus; Usutu virus; Germany; monitoring
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Michel, F.; Sieg, M.; Fischer, D.; Keller, M.; Eiden, M.; Reuschel, M.; Schmidt, V.; Schwehn, R.; Rinder, M.; Urbaniak, S.; Müller, K.; Schmoock, M.; Lühken, R.; Wysocki, P.; Fast, C.; Lierz, M.; Korbel, R.; Vahlenkamp, T.W.; Groschup, M.H.; Ziegler, U. Evidence for West Nile Virus and Usutu Virus Infections in Wild and Resident Birds in Germany, 2017 and 2018. Viruses 2019, 11, 674.

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