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The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future

1
Agence Nationale de Sécurité Sanitaire de L’alimentation, de L’environnement et du Travail, Laboratoire de Lyon, Unite Virologie, 69007 Lyon, France
2
Centre de Biologie Pour la Gestion des Populations (CBGP), INRA, CIRAD, IRD, Montpellier SupAgro, Univ. Montpellier, 34000 Montpellier, France
*
Author to whom correspondence should be addressed.
Those authors contributed equally to the work.
Viruses 2019, 11(7), 664; https://doi.org/10.3390/v11070664
Received: 27 June 2019 / Revised: 9 July 2019 / Accepted: 18 July 2019 / Published: 19 July 2019
(This article belongs to the Special Issue Hantaviruses)
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PDF [387 KB, uploaded 22 July 2019]
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Abstract

Due to their large geographic distribution and potential high mortality rates in human infections, hantaviruses constitute a worldwide threat to public health. As such, they have been the subject of a large array of clinical, virological and eco-evolutionary studies. Many experiments have been conducted in vitro or on animal models to identify the mechanisms leading to pathogenesis in humans and to develop treatments of hantavirus diseases. Experimental research has also been dedicated to the understanding of the relationship between hantaviruses and their reservoirs. However, these studies remain too scarce considering the diversity of hantavirus/reservoir pairs identified, and the wide range of issues that need to be addressed. In this review, we present a synthesis of the experimental studies that have been conducted on hantaviruses and their reservoirs. We aim at summarizing the knowledge gathered from this research, and to emphasize the gaps that need to be filled. Despite the many difficulties encountered to carry hantavirus experiments, we advocate for the need of such studies in the future, at the interface of evolutionary ecology and virology. They are critical to address emerging areas of research, including hantavirus evolution and the epidemiological consequences of individual variation in infection outcomes. View Full-Text
Keywords: hantavirus; experimentations; reservoirs; transmission; spill-over; persistence; immunity; super-spreader; evolutionary ecology; virology hantavirus; experimentations; reservoirs; transmission; spill-over; persistence; immunity; super-spreader; evolutionary ecology; virology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Madrières, S.; Castel, G.; Murri, S.; Vulin, J.; Marianneau, P.; Charbonnel, N. The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future. Viruses 2019, 11, 664.

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