Next Article in Journal
Molecular Analysis of the Complete Genome of a Simian Foamy Virus Infecting Hylobates pileatus (pileated gibbon) Reveals Ancient Co-Evolution with Lesser Apes
Next Article in Special Issue
Human Antimicrobial Peptides as Therapeutics for Viral Infections
Previous Article in Journal
A Nymphalid-Infecting Group I Alphabaculovirus Isolated from the Major Passion Fruit Caterpillar Pest Dione juno juno (Lepidoptera: Nymphalidae)
Previous Article in Special Issue
Genistein Has Antiviral Activity against Herpes B Virus and Acts Synergistically with Antiviral Treatments to Reduce Effective Dose
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Viruses
Volume 11
Issue 7
10.3390/v11070604
viruses-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo

by
Kiramage Chathuranga
1,
Myun Soo Kim
2,
Hyun-Cheol Lee
1,
Tae-Hwan Kim
1,
Jae-Hoon Kim
1,3,
W. A. Gayan Chathuranga
1,
Pathum Ekanayaka
1,
H. M. S. M. Wijerathne
1,
Won-Kyung Cho
4,
Hong Ik Kim
2,
Jin Yeul Ma
4 and
Jong-Soo Lee
1,*,†
1
Microbiology Laboratory, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea
2
Vitabio Corporation, Daejeon 34540, Korea
3
Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology (UST), Daejeon 34141, Korea
4
Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Korea
*
Author to whom correspondence should be addressed.
†
Current address: College of Veterinary Medicine, Chungnam National University, 99 Daehak-ro, Yuseong-Gu, Daejeon 34134, Korea.
Viruses 2019, 11(7), 604; https://doi.org/10.3390/v11070604
Submission received: 17 April 2019 / Revised: 1 July 2019 / Accepted: 1 July 2019 / Published: 3 July 2019
(This article belongs to the Special Issue Antiviral Agents)
Browse Figures
Versions Notes

Abstract

The herbs Plantago asiatica and Clerodendrum trichotomum have been commonly used for centuries in indigenous and folk medicine in tropical and subtropical regions of the world. In this study, we show that extracts from these herbs have antiviral effects against the respiratory syncytial virus (RSV) in vitro cell cultures and an in vivo mouse model. Treatment of HEp2 cells and A549 cells with a non-cytotoxic concentration of Plantago asiatica or Clerodendrum trichotomum extract significantly reduced RSV replication, RSV-induced cell death, RSV gene transcription, RSV protein synthesis, and also blocked syncytia formation. Interestingly, oral inoculation with each herb extract significantly improved viral clearance in the lungs of BALB/c mice. Based on reported information and a high-performance liquid chromatography (HPLC) analysis, the phenolic glycoside acteoside was identified as an active chemical component of both herb extracts. An effective dose of acteoside exhibited similar antiviral effects as each herb extract against RSV in vitro and in vivo. Collectively, these results suggest that extracts of Plantago asiatica and Clerodendrum trichotomum could provide a potent natural source of an antiviral drug candidate against RSV infection.
Keywords: Plantago asiatica; Clerodendrum trichotomum; RSV; therapeutic effects; acteoside Plantago asiatica; Clerodendrum trichotomum; RSV; therapeutic effects; acteoside

Share and Cite

MDPI and ACS Style

Chathuranga, K.; Kim, M.S.; Lee, H.-C.; Kim, T.-H.; Kim, J.-H.; Gayan Chathuranga, W.A.; Ekanayaka, P.; Wijerathne, H.M.S.M.; Cho, W.-K.; Kim, H.I.; et al. Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo. Viruses 2019, 11, 604. https://doi.org/10.3390/v11070604

AMA Style

Chathuranga K, Kim MS, Lee H-C, Kim T-H, Kim J-H, Gayan Chathuranga WA, Ekanayaka P, Wijerathne HMSM, Cho W-K, Kim HI, et al. Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo. Viruses. 2019; 11(7):604. https://doi.org/10.3390/v11070604

Chicago/Turabian Style

Chathuranga, Kiramage, Myun Soo Kim, Hyun-Cheol Lee, Tae-Hwan Kim, Jae-Hoon Kim, W. A. Gayan Chathuranga, Pathum Ekanayaka, H. M. S. M. Wijerathne, Won-Kyung Cho, Hong Ik Kim, and et al. 2019. "Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo" Viruses 11, no. 7: 604. https://doi.org/10.3390/v11070604

APA Style

Chathuranga, K., Kim, M. S., Lee, H.-C., Kim, T.-H., Kim, J.-H., Gayan Chathuranga, W. A., Ekanayaka, P., Wijerathne, H. M. S. M., Cho, W.-K., Kim, H. I., Ma, J. Y., & Lee, J.-S. (2019). Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo. Viruses, 11(7), 604. https://doi.org/10.3390/v11070604

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop