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Viruses 2019, 11(3), 273; https://doi.org/10.3390/v11030273

Meal for Two: Human Cytomegalovirus-Induced Activation of Cellular Metabolism

1
Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
2
Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
*
Author to whom correspondence should be addressed.
Received: 13 February 2019 / Revised: 12 March 2019 / Accepted: 13 March 2019 / Published: 19 March 2019
(This article belongs to the Special Issue Viruses and Cellular Metabolism)
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Abstract

Viruses are parasites that depend on the host cell’s metabolic resources to provide the energy and molecular building blocks necessary for the production of viral progeny. It has become increasingly clear that viruses extensively modulate the cellular metabolic network to support productive infection. Here, we review the numerous ways through which human cytomegalovirus (HCMV) modulates cellular metabolism, highlighting known mechanisms of HCMV-mediated metabolic manipulation and identifying key outstanding questions that remain to be addressed. View Full-Text
Keywords: human cytomegalovirus; HCMV; metabolism; host–virus interactions; glycolysis; glutaminolysis; amino acid; fatty acids; pyrimidine; mTOR human cytomegalovirus; HCMV; metabolism; host–virus interactions; glycolysis; glutaminolysis; amino acid; fatty acids; pyrimidine; mTOR
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Rodríguez-Sánchez, I.; Munger, J. Meal for Two: Human Cytomegalovirus-Induced Activation of Cellular Metabolism. Viruses 2019, 11, 273.

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