Molecular Phylogeny of Mobatviruses (Hantaviridae) in Myanmar and Vietnam
by
Satoru Arai 1, Fuka Kikuchi 1,2, Saw Bawm 3
, Nguyễn Trường Sơn 4,5, Kyaw San Lin 6, Vương Tân Tú 4,5, Keita Aoki 1,7, Kimiyuki Tsuchiya 8, Keiko Tanaka-Taya 1, Shigeru Morikawa 9, Kazunori Oishi 1 and Richard Yanagihara 10,*
Satoru Arai 1, Fuka Kikuchi 1,2, Saw Bawm 3, Nguyễn Trường Sơn 4,5, Kyaw San Lin 6, Vương Tân Tú 4,5, Keita Aoki 1,7, Kimiyuki Tsuchiya 8, Keiko Tanaka-Taya 1, Shigeru Morikawa 9, Kazunori Oishi 1 and Richard Yanagihara 10,*
1
Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan
2
Department of Chemistry, Faculty of Science, Tokyo University of Science, Tokyo 162-8601, Japan
3
Department of Pharmacology and Parasitology, University of Veterinary Science, Yezin, Nay Pyi Taw 15013, Myanmar
4
Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Hanoi, Vietnam
5
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam
6
Department of Aquaculture and Aquatic Disease, University of Veterinary Science, Yezin, Nay Pyi Taw 15013, Myanmar
7
Department of Liberal Arts, Faculty of Science, Tokyo University of Science, Tokyo 162-8601, Japan
8
Laboratory of Bioresources, Applied Biology Co., Ltd., Tokyo 107-0062, Japan
9
Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo 162-8640, Japan
10
Pacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(3), 228; https://doi.org/10.3390/v11030228
Received: 8 February 2019 / Revised: 28 February 2019 / Accepted: 1 March 2019 / Published: 7 March 2019
(This article belongs to the Special Issue Viruses and Bats 2019)
The discovery of highly divergent lineages of hantaviruses (family Hantaviridae) in shrews, moles, and bats of multiple species raises the possibility that non-rodent hosts may have played a significant role in their evolutionary history. To further investigate this prospect, total RNA was extracted from RNAlater®-preserved lung tissues of 277 bats (representing five families, 14 genera and 40 species), captured in Myanmar and Vietnam during 2013–2016. Hantavirus RNA was detected in two of 15 black-bearded tomb bats (Taphozous melanopogon) and two of 26 Pomona roundleaf bats (Hipposideros pomona) in Myanmar, and in three of six ashy leaf-nosed bats (Hipposideros cineraceus) in Vietnam. Pair-wise alignment and comparison of coding regions of the S, M, and L segments of hantaviruses from Taphozous and Hipposideros bats revealed high nucleotide and amino acid sequence similarities to prototype Láibīn virus (LAIV) and Xuân Sơn virus (XSV), respectively. Phylogenetic analyses, generated by maximum-likelihood and Bayesian methods, showed a geographic clustering of LAIV strains from China and Myanmar, but not of XSV strains from China and Vietnam. These findings confirm that the black-bearded tomb bat is the natural reservoir of LAIV, and that more than one species of Hipposideros bats can host XSV.
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Keywords:
Hantaviridae; Mobatvirus; phylogeny
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MDPI and ACS Style
Arai, S.; Kikuchi, F.; Bawm, S.; Sơn, N.T.; Lin, K.S.; Tú, V.T.; Aoki, K.; Tsuchiya, K.; Tanaka-Taya, K.; Morikawa, S.; Oishi, K.; Yanagihara, R. Molecular Phylogeny of Mobatviruses (Hantaviridae) in Myanmar and Vietnam. Viruses 2019, 11, 228.
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