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Viruses 2019, 11(2), 132;

Crosstalk between Autophagy and Type I Interferon Responses in Innate Antiviral Immunity

Department of Microbiology, Anhui Medical University, Hefei 230032, China
Wuhu Interferon Bio-Products Industry Research Institute Co., Ltd., Wuhu 241000, China
Authors to whom correspondence should be addressed.
Received: 18 December 2018 / Revised: 25 January 2019 / Accepted: 28 January 2019 / Published: 1 February 2019
(This article belongs to the Section Antivirals & Vaccines)
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Autophagy exhibits dual effects during viral infections, promoting the clearance of viral components and activating the immune system to produce antiviral cytokines. However, some viruses impair immune defenses by collaborating with autophagy. Mounting evidence suggests that the interaction between autophagy and innate immunity is critical to understanding the contradictory roles of autophagy. Type I interferon (IFN-I) is a crucial antiviral factor, and studies have indicated that autophagy affects IFN-I responses by regulating IFN-I and its receptors expression. Similarly, IFN-I and interferon-stimulated gene (ISG) products can harness autophagy to regulate antiviral immunity. Crosstalk between autophagy and IFN-I responses could be a vital aspect of the molecular mechanisms involving autophagy in innate antiviral immunity. This review briefly summarizes the approaches by which autophagy regulates antiviral IFN-I responses and highlights the recent advances on the mechanisms by which IFN-I and ISG products employ autophagy against viruses. View Full-Text
Keywords: antiviral immunity; type I interferon; autophagy antiviral immunity; type I interferon; autophagy

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Tian, Y.; Wang, M.-L.; Zhao, J. Crosstalk between Autophagy and Type I Interferon Responses in Innate Antiviral Immunity. Viruses 2019, 11, 132.

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