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Viruses 2019, 11(2), 119; https://doi.org/10.3390/v11020119

Chewing the Fat: The Conserved Ability of DNA Viruses to Hijack Cellular Lipid Metabolism

1
Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
2
Department of Microbiology, University of Washington, Seattle, WA 98101, USA
3
Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98101, USA
4
Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
*
Author to whom correspondence should be addressed.
Received: 3 January 2019 / Revised: 25 January 2019 / Accepted: 26 January 2019 / Published: 29 January 2019
(This article belongs to the Special Issue Viruses and Cellular Metabolism)
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Abstract

Viruses manipulate numerous host factors and cellular pathways to facilitate the replication of viral genomes and the production of infectious progeny. One way in which viruses interact with cells is through the utilization and exploitation of the host lipid metabolism. While it is likely that most—if not all—viruses require lipids or intermediates of lipid synthesis to replicate, many viruses also actively induce lipid metabolic pathways to sustain a favorable replication environment. From the formation of membranous replication compartments, to the generation of ATP or protein modifications, viruses exhibit differing requirements for host lipids. Thus, while the exploitation of lipid metabolism is a common replication strategy, diverse viruses employ a plethora of mechanisms to co-opt these critical cellular pathways. Here, we review recent literature regarding the exploitation of host lipids and lipid metabolism specifically by DNA viruses. Importantly, furthering the understanding of the viral requirements for host lipids may offer new targets for antiviral therapeutics and provide opportunities to repurpose the numerous FDA-approved compounds targeting lipid metabolic pathways as antiviral agents. View Full-Text
Keywords: DNA virus; lipids; fatty acids; cholesterol; herpesvirus; MHV68 DNA virus; lipids; fatty acids; cholesterol; herpesvirus; MHV68
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Lange, P.T.; Lagunoff, M.; Tarakanova, V.L. Chewing the Fat: The Conserved Ability of DNA Viruses to Hijack Cellular Lipid Metabolism. Viruses 2019, 11, 119.

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