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SV40 Hijacks Cellular Transport, Membrane Penetration, and Disassembly Machineries to Promote Infection

Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 3043, Ann Arbor, MI 48109, USA
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Viruses 2019, 11(10), 917; https://doi.org/10.3390/v11100917
Received: 4 September 2019 / Revised: 23 September 2019 / Accepted: 29 September 2019 / Published: 5 October 2019
(This article belongs to the Special Issue Viral Entry Pathways)
During entry, a virus must be transported through the endomembrane system of the host cell, penetrate a cellular membrane, and undergo capsid disassembly, to reach the cytosol and often the nucleus in order to cause infection. To do so requires the virus to coordinately exploit the action of cellular membrane transport, penetration, and disassembly machineries. How this is accomplished remains enigmatic for many viruses, especially for viruses belonging to the nonenveloped virus family. In this review, we present the current model describing infectious entry of the nonenveloped polyomavirus (PyV) SV40. Insights from SV40 entry are likely to provide strategies to combat PyV-induced diseases, and to illuminate cellular trafficking, membrane transport, and disassembly mechanisms. View Full-Text
Keywords: SV40; nonenveloped virus; endoplasmic reticulum; membrane penetration; viral disassembly SV40; nonenveloped virus; endoplasmic reticulum; membrane penetration; viral disassembly
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MDPI and ACS Style

Chen, Y.-J.; Liu, X.; Tsai, B. SV40 Hijacks Cellular Transport, Membrane Penetration, and Disassembly Machineries to Promote Infection. Viruses 2019, 11, 917.

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