Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus
AbstractHeme oxygenase-1 (HO-1), a rate-limiting enzyme involved in the degradation of heme, is induced in response to a wide range of stress conditions. HO-1 exerts antiviral activity against a broad range of viruses, including the Hepatitis C virus, the human immunodeficiency virus, and the dengue virus by inhibiting viral growth. It has been reported that HO-1 displays antiviral activity against the Zika virus (ZIKV) but the mechanisms of viral inhibition remain largely unknown. Using a ZIKV RNA replicon with the Green Fluorescent Protein (GFP) as a reporter protein, we were able to show that HO-1 expression resulted in the inhibition of viral RNA replication. Conversely, we observed a decrease in HO-1 expression in cells replicating the ZIKV RNA replicon. The study of human cells infected with ZIKV showed that the HO-1 expression level was significantly lower once viral replication was established, thereby limiting the antiviral effect of HO-1. Our work highlights the capacity of ZIKV to thwart the anti-replicative activity of HO-1 in human cells. Therefore, the modulation of HO-1 as a novel therapeutic strategy against ZIKV infection may display limited effect. View Full-Text
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El Kalamouni, C.; Frumence, E.; Bos, S.; Turpin, J.; Nativel, B.; Harrabi, W.; Wilkinson, D.A.; Meilhac, O.; Gadea, G.; Desprès, P.; Krejbich-Trotot, P.; Viranaïcken, W. Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus. Viruses 2019, 11, 2.
El Kalamouni C, Frumence E, Bos S, Turpin J, Nativel B, Harrabi W, Wilkinson DA, Meilhac O, Gadea G, Desprès P, Krejbich-Trotot P, Viranaïcken W. Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus. Viruses. 2019; 11(1):2.Chicago/Turabian Style
El Kalamouni, Chaker; Frumence, Etienne; Bos, Sandra; Turpin, Jonathan; Nativel, Brice; Harrabi, Wissal; Wilkinson, David A.; Meilhac, Olivier; Gadea, Gilles; Desprès, Philippe; Krejbich-Trotot, Pascale; Viranaïcken, Wildriss. 2019. "Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus." Viruses 11, no. 1: 2.
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