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Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus

Université de La Réunion, INSERM UMR 1187, CNRS 9192, IRD 249 UMR PIMIT, Processus Infectieux en Milieu Insulaire Tropical, Plateforme CYROI, 2, rue Maxime Rivière, F-97490 Sainte-Clotilde, France
Université de la Réunion, Inserm, UMR 1188 Diabète Athérothrombose Thérapies Réunion Océan Indien (DéTROI), F-97490 Sainte-Clotilde, France
CHU de La Réunion, Saint-Denis de La Réunion, F-97400 Bellepierre, France
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2019, 11(1), 2;
Received: 15 October 2018 / Revised: 13 December 2018 / Accepted: 18 December 2018 / Published: 20 December 2018
(This article belongs to the Special Issue New Advances on Zika Virus Research)
Heme oxygenase-1 (HO-1), a rate-limiting enzyme involved in the degradation of heme, is induced in response to a wide range of stress conditions. HO-1 exerts antiviral activity against a broad range of viruses, including the Hepatitis C virus, the human immunodeficiency virus, and the dengue virus by inhibiting viral growth. It has been reported that HO-1 displays antiviral activity against the Zika virus (ZIKV) but the mechanisms of viral inhibition remain largely unknown. Using a ZIKV RNA replicon with the Green Fluorescent Protein (GFP) as a reporter protein, we were able to show that HO-1 expression resulted in the inhibition of viral RNA replication. Conversely, we observed a decrease in HO-1 expression in cells replicating the ZIKV RNA replicon. The study of human cells infected with ZIKV showed that the HO-1 expression level was significantly lower once viral replication was established, thereby limiting the antiviral effect of HO-1. Our work highlights the capacity of ZIKV to thwart the anti-replicative activity of HO-1 in human cells. Therefore, the modulation of HO-1 as a novel therapeutic strategy against ZIKV infection may display limited effect. View Full-Text
Keywords: antiviral; heme-oxygenase 1; Zika virus; viral replication antiviral; heme-oxygenase 1; Zika virus; viral replication
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MDPI and ACS Style

El Kalamouni, C.; Frumence, E.; Bos, S.; Turpin, J.; Nativel, B.; Harrabi, W.; Wilkinson, D.A.; Meilhac, O.; Gadea, G.; Desprès, P.; Krejbich-Trotot, P.; Viranaïcken, W. Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus. Viruses 2019, 11, 2.

AMA Style

El Kalamouni C, Frumence E, Bos S, Turpin J, Nativel B, Harrabi W, Wilkinson DA, Meilhac O, Gadea G, Desprès P, Krejbich-Trotot P, Viranaïcken W. Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus. Viruses. 2019; 11(1):2.

Chicago/Turabian Style

El Kalamouni, Chaker, Etienne Frumence, Sandra Bos, Jonathan Turpin, Brice Nativel, Wissal Harrabi, David A. Wilkinson, Olivier Meilhac, Gilles Gadea, Philippe Desprès, Pascale Krejbich-Trotot, and Wildriss Viranaïcken. 2019. "Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus" Viruses 11, no. 1: 2.

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