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Feline APOBEC3s, Barriers to Cross-Species Transmission of FIV?

Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany
Division of Applied Life Science (BK21Plus), Graduate School of Gyeongsang National University, Jinju 52828, Korea
Author to whom correspondence should be addressed.
Viruses 2018, 10(4), 186;
Received: 27 March 2018 / Revised: 6 April 2018 / Accepted: 7 April 2018 / Published: 10 April 2018
(This article belongs to the Special Issue Nonprimate Lentivirus)
The replication of lentiviruses highly depends on host cellular factors, which defines their species-specific tropism. Cellular restriction factors that can inhibit lentiviral replication were recently identified. Feline immunodeficiency virus (FIV) was found to be sensitive to several feline cellular restriction factors, such as apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3 (APOBEC3) and tetherin, but FIV evolved to counteract them. Here, we describe the molecular mechanisms by which feline APOBEC3 restriction factors inhibit FIV replication and discuss the molecular interaction of APOBEC3 proteins with the viral antagonizing protein Vif. We speculate that feline APOBEC3 proteins could explain some of the observed FIV cross-species transmissions described in wild Felids. View Full-Text
Keywords: FIV; restriction factors; feline APOBEC3; cross-species transmission FIV; restriction factors; feline APOBEC3; cross-species transmission
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Zhang, Z.; Gu, Q.; Marino, D.; Lee, K.-L.; Kong, I.-K.; Häussinger, D.; Münk, C. Feline APOBEC3s, Barriers to Cross-Species Transmission of FIV? Viruses 2018, 10, 186.

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