Next Article in Journal
Feline APOBEC3s, Barriers to Cross-Species Transmission of FIV?
Next Article in Special Issue
Remembering Jan Svoboda: A Personal Reflection
Previous Article in Journal
Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses
Previous Article in Special Issue
Deep Sequencing-Based Transcriptome Profiling Reveals Avian Interferon-Stimulated Genes and Provides Comprehensive Insight into Newcastle Disease Virus-Induced Host Responses
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Viruses 2018, 10(4), 185;

Remnants of an Ancient Deltaretrovirus in the Genomes of Horseshoe Bats (Rhinolophidae)

Institute of Molecular Genetics, The Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic
MRC-University of Glasgow, Centre for Virus Research, 464 Bearsden Road, Glasgow G12 8TA, UK
Department of Zoology, Charles University, Vinicna 7, 12844 Prague, Czech Republic
Department of Zoology, National Museum (Natural History), Vaclavske nam. 68, 11579 Prague, Czech Republic
Department of Biology and Ecology, University of Ostrava, Chitussiho 10, 71000 Ostrava, Czech Republic
Department of Zoology, Hungarian Natural History Musem, Baross Utca 13, 1088 Budapest, Hungary
Author to whom correspondence should be addressed.
Current address: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, 4 Center Drive, Bethesda, MD 20892, USA.
Received: 28 February 2018 / Revised: 31 March 2018 / Accepted: 7 April 2018 / Published: 10 April 2018
PDF [4650 KB, uploaded 3 May 2018]


Endogenous retrovirus (ERV) sequences provide a rich source of information about the long-term interactions between retroviruses and their hosts. However, most ERVs are derived from a subset of retrovirus groups, while ERVs derived from certain other groups remain extremely rare. In particular, only a single ERV sequence has been identified that shows evidence of being related to an ancient Deltaretrovirus, despite the large number of vertebrate genome sequences now available. In this report, we identify a second example of an ERV sequence putatively derived from a past deltaretroviral infection, in the genomes of several species of horseshoe bats (Rhinolophidae). This sequence represents a fragment of viral genome derived from a single integration. The time of the integration was estimated to be 11–19 million years ago. This finding, together with the previously identified endogenous Deltaretrovirus in long-fingered bats (Miniopteridae), suggest a close association of bats with ancient deltaretroviruses. View Full-Text
Keywords: retrovirus; evolution; Deltaretrovirus; endogenous retrovirus; genomics; bats retrovirus; evolution; Deltaretrovirus; endogenous retrovirus; genomics; bats

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Hron, T.; Farkašová, H.; Gifford, R.J.; Benda, P.; Hulva, P.; Görföl, T.; Pačes, J.; Elleder, D. Remnants of an Ancient Deltaretrovirus in the Genomes of Horseshoe Bats (Rhinolophidae). Viruses 2018, 10, 185.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top