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A Wake-Up Call: We Need Phage Therapy Now

by Karin Moelling 1,2,*,†, Felix Broecker 3,*,† and Christian Willy 4
1
Institute of Medical Microbiology, University of Zurich, 8006 Zurich, Switzerland
2
Max Planck Institute for molecular Genetics, 14195 Berlin, Germany
3
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4
Department Trauma & Orthopedic Surgery, Septic & Reconstructive Surgery, Research and Treatment Center for Complex Combat Injuries, Military Hospital Berlin, 10115 Berlin, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Viruses 2018, 10(12), 688; https://doi.org/10.3390/v10120688
Received: 26 October 2018 / Revised: 27 November 2018 / Accepted: 3 December 2018 / Published: 5 December 2018
(This article belongs to the Special Issue Viruses of Microbes V: Biodiversity and Future Applications)
The rise of multidrug-resistant bacteria has resulted in an increased interest in phage therapy, which historically preceded antibiotic treatment against bacterial infections. To date, there have been no reports of serious adverse events caused by phages. They have been successfully used to cure human diseases in Eastern Europe for many decades. More recently, clinical trials and case reports for a variety of indications have shown promising results. However, major hurdles to the introduction of phage therapy in the Western world are the regulatory and legal frameworks. Present regulations may take a decade or longer to be fulfilled. It is of urgent need to speed up the availability of phage therapy. View Full-Text
Keywords: phages; phage therapy; Helsinki declaration; regulation; magistral preparation phages; phage therapy; Helsinki declaration; regulation; magistral preparation
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Moelling, K.; Broecker, F.; Willy, C. A Wake-Up Call: We Need Phage Therapy Now. Viruses 2018, 10, 688.

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