Synthesis of Monodispersed Ag-Doped Bioactive Glass Nanoparticles via Surface Modification
by
Dominika Kozon 1,2, Kai Zheng 1,*
, Elena Boccardi 1, Yufang Liu 3, Liliana Liverani 1 and Aldo R. Boccaccini 1
Dominika Kozon 1,2, Kai Zheng 1,*, Elena Boccardi 1, Yufang Liu 3, Liliana Liverani 1 and Aldo R. Boccaccini 1
1
Institute of Biomaterials, Department of Material Science and Engineering, University of Erlangen-Nuremberg, 91058 Erlangen, Germany
2
Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland
3
Food Chemistry Unit, Department of Chemistry and Pharmacy, University of Erlangen-Nuremberg, Schuhstr. 19, 91052 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Gigliola Lusvardi
Materials 2016, 9(4), 225; https://doi.org/10.3390/ma9040225
Received: 6 February 2016 / Revised: 15 March 2016 / Accepted: 15 March 2016 / Published: 24 March 2016
(This article belongs to the Special Issue Bioactive Glasses)
Monodispersed spherical Ag-doped bioactive glass nanoparticles (Ag-BGNs) were synthesized by a modified Stöber method combined with surface modification. The surface modification was carried out at 25, 60, and 80 °C, respectively, to investigate the influence of processing temperature on particle properties. Energy-dispersive X-ray spectroscopy (EDS) results indicated that higher temperatures facilitate the incorporation of Ag. Hydroxyapatite (HA) formation on Ag-BGNs was detected upon immersion of the particles in simulated body fluid for 7 days, which indicated that Ag-BGNs maintained high bioactivity after surface modification. The conducted antibacterial assay confirmed that Ag-BGNs had an antibacterial effect on E. coli. The above results thereby suggest that surface modification is an effective way to incorporate Ag into BGNs and that the modified BGNs can remain monodispersed as well as exhibit bioactivity and antibacterial capability for biomedical applications.
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Keywords:
bioactive glass nanoparticle; bioactivity; silver; surface modification; antibacterial activity
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MDPI and ACS Style
Kozon, D.; Zheng, K.; Boccardi, E.; Liu, Y.; Liverani, L.; Boccaccini, A.R. Synthesis of Monodispersed Ag-Doped Bioactive Glass Nanoparticles via Surface Modification. Materials 2016, 9, 225.
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