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Open AccessArticle

Triggered Release from Thermoresponsive Polymersomes with Superparamagnetic Membranes

1
Institute for Biologically Inspired Materials, Department of Nanobiotechnology, University of Natural Resources and Life Sciences, Vienna, Muthgasse 11, Vienna 1190, Austria
2
School of Materials Science and Engineering, Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, 637553 Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Beatriz Noheda
Materials 2016, 9(1), 29; https://doi.org/10.3390/ma9010029
Received: 29 October 2015 / Revised: 14 December 2015 / Accepted: 28 December 2015 / Published: 6 January 2016
(This article belongs to the Section Advanced Composites)
Magnetic polymersomes were prepared by self-assembly of the amphiphilic block copolymer poly(isoprene-b-N-isopropylacrylamide) with monodisperse hydrophobic superparamagnetic iron oxide nanoparticles (SPION). The specifically designed thermoresponsive block copolymer allowed for efficient incorporation of the hydrophobic nanoparticles in the membrane core and encapsulation of the water soluble dye calcein in the lumen of the vesicles. Magnetic heating of the embedded SPIONs led to increased bilayer permeability through dehydration of the thermoresponsive PNIPAM block. The entrapped calcein could therefore be released in controlled doses solely through exposure to pulses of an alternating magnetic field. This hybrid SPION-polymersome system demonstrates a possible direction for release applications that merges rational polymersome design with addressed external magnetic field-triggered release through embedded nanomaterials. View Full-Text
Keywords: superparamagnetic iron oxide nanoparticle; thermoresponsive polymer; magneto-polymersome; magneto-thermal release; calcein assay superparamagnetic iron oxide nanoparticle; thermoresponsive polymer; magneto-polymersome; magneto-thermal release; calcein assay
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MDPI and ACS Style

Bixner, O.; Kurzhals, S.; Virk, M.; Reimhult, E. Triggered Release from Thermoresponsive Polymersomes with Superparamagnetic Membranes. Materials 2016, 9, 29.

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