Materials 2015, 8(3), 1341-1349; https://doi.org/10.3390/ma8031341
Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-Cyclodextrin
Faculty of Pharmaceutical Sciences, Josai University, Keyakidai, Sakado, Saitama 350-0295, Japan
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Academic Editor: Carsten Werner
Received: 31 January 2015 / Revised: 9 March 2015 / Accepted: 16 March 2015 / Published: 20 March 2015
(This article belongs to the Special Issue Functional Materials for Bio-Sensing, Bio-Imaging, and Controlled Release)
Abstract
We have designed a sugar-responsive pseudopolyrotaxane (PPRX) by combining phenylboronic acid-modified polyethylene glycol (PBA–PEG) and γ-cyclodextrin. Phenylboronic acid (PBA) was used as a sugar-recognition motif in the PPRX because PBA reacts with a diol portion of the sugar molecule and forms a cyclic ester. When D-fructose or D-glucose was added to a suspension of PPRX, PPRX disintegrated, depending on the concentration of the sugars. Interestingly, catechol does not show a response although catechol has a high affinity for PBA. We analyzed the response mechanism of PPRX by considering equilibria. View Full-TextKeywords:
pseudopolyrotaxane; cyclodextrin; boronic acid; drug delivery; stimuli-responsive material
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Seki, T.; Namiki, M.; Egawa, Y.; Miki, R.; Juni, K.; Seki, T. Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-Cyclodextrin. Materials 2015, 8, 1341-1349.
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