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Open AccessReview

Nanomaterials-Based Fluorimetric Methods for MicroRNAs Detection

by Ming La 1, Lin Liu 2,* and Bin-Bin Zhou 1,2,*
1
College of Chemistry and Chemical Engineering, Pingdingshan University, Pingdingshan 467000, Henan, China
2
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, Henan, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Jun-ichi Anzai
Materials 2015, 8(5), 2809-2829; https://doi.org/10.3390/ma8052809
Received: 17 April 2015 / Revised: 6 May 2015 / Accepted: 12 May 2015 / Published: 22 May 2015
MicroRNAs (miRNAs) are small endogenous non-coding RNAs of ~22 nucleotides that play important functions in the regulation of many biological processes, including cell proliferation, differentiation, and death. Since their expression has been in close association with the development of many diseases, recently, miRNAs have been regarded as clinically important biomarkers and drug discovery targets. However, because of the short length, high sequence similarity and low abundance of miRNAs in vivo, it is difficult to realize the sensitive and selective detection of miRNAs with conventional methods. In line with the rapid development of nanotechnology, nanomaterials have attracted great attention and have been intensively studied in biological analysis due to their unique chemical, physical and size properties. In particular, fluorimetric methodologies in combination with nanotechnology are especially rapid, sensitive and efficient. The aim of this review is to provide insight into nanomaterials-based fluorimetric methods for the detection of miRNAs, including metal nanomaterials, quantum dots (QDs), graphene oxide (GO) and silicon nanoparticles. View Full-Text
Keywords: microRNAs; biomarker; fluorescence; metal nanomaterials; quantum dots; graphene oxide; silicon nanoparticles microRNAs; biomarker; fluorescence; metal nanomaterials; quantum dots; graphene oxide; silicon nanoparticles
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La, M.; Liu, L.; Zhou, B.-B. Nanomaterials-Based Fluorimetric Methods for MicroRNAs Detection. Materials 2015, 8, 2809-2829.

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