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Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template

1
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China
2
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China
*
Author to whom correspondence should be addressed.
Academic Editor: Naozumi Teramoto
Materials 2015, 8(12), 8097-8105; https://doi.org/10.3390/ma8125440
Received: 26 October 2015 / Revised: 16 November 2015 / Accepted: 20 November 2015 / Published: 30 November 2015
(This article belongs to the Section Biomaterials)
In this study, a novel biocompatible hydroxyapatite (HA) was synthesized by using chitosan oligosaccharide (COS) as a template. These HA samples were studied by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). The biocompatibility of HA samples was evaluated via cell viability, cell morphology and alkaline phosphatase staining of MG-63 cell lines. The results show that HA synthesized in the presence of COS was favorable to proliferation and osteogenic differentiation of MG-63 cells. These hydroxyapatites are potentially attractive biomaterials for bone tissue engineering applications. View Full-Text
Keywords: chitosan oligosaccharide; hydroxyapatite; cytotoxicity; MG-63 cell chitosan oligosaccharide; hydroxyapatite; cytotoxicity; MG-63 cell
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Wang, J.; Liu, G.; Chen, J.; Zhao, B.; Zhu, P. Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template. Materials 2015, 8, 8097-8105.

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