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Materials 2015, 8(12), 8097-8105;

Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template

School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials and Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China
Author to whom correspondence should be addressed.
Academic Editor: Naozumi Teramoto
Received: 26 October 2015 / Revised: 16 November 2015 / Accepted: 20 November 2015 / Published: 30 November 2015
(This article belongs to the Section Biomaterials)
Full-Text   |   PDF [4735 KB, uploaded 30 November 2015]   |  


In this study, a novel biocompatible hydroxyapatite (HA) was synthesized by using chitosan oligosaccharide (COS) as a template. These HA samples were studied by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). The biocompatibility of HA samples was evaluated via cell viability, cell morphology and alkaline phosphatase staining of MG-63 cell lines. The results show that HA synthesized in the presence of COS was favorable to proliferation and osteogenic differentiation of MG-63 cells. These hydroxyapatites are potentially attractive biomaterials for bone tissue engineering applications. View Full-Text
Keywords: chitosan oligosaccharide; hydroxyapatite; cytotoxicity; MG-63 cell chitosan oligosaccharide; hydroxyapatite; cytotoxicity; MG-63 cell

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Wang, J.; Liu, G.; Chen, J.; Zhao, B.; Zhu, P. Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template. Materials 2015, 8, 8097-8105.

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