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Materials
Volume 18
Issue 22
10.3390/ma18225227
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Systematic Review

Evaluating the Clinical Efficacy of Membrane-Assisted Regenerative Therapy in Peri-Implantitis Management: A Comprehensive Review Incorporating Systematic Review Evidence

by
Young Joon Cho
1,2,†,
Yong Tak Jeong
1,2,†,
Hyun Nyun Woo
3,
Hyun Woo Cho
4,
Min Gu Kang
5,
Sung-Min Hwang
2,* and
Jae-Mok Lee
2,*
1
Mac Dental Clinic, Daegu 42117, Republic of Korea
2
Department of Periodontology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea
3
Private Practice, New York, NY 10075, USA
4
Department of Oral & Maxillofacial Surgery, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA 02118, USA
5
Private Practice, Gumi-si 39236, Republic of Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Materials 2025, 18(22), 5227; https://doi.org/10.3390/ma18225227 (registering DOI)
Submission received: 13 October 2025 / Revised: 5 November 2025 / Accepted: 13 November 2025 / Published: 18 November 2025
(This article belongs to the Special Issue Advanced Materials for Oral Application (3rd Edition))
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Abstract

Peri-implantitis (PI) is characterized by inflammatory tissue destruction and alveolar bone loss surrounding dental implants, posing clinical challenges. To promote bone regeneration, clinicians often use resorbable or non-resorbable membranes in combination with bone grafts or biologic agents. Despite their widespread application in PI management, the clinical efficacy of these approaches remains uncertain. Therefore, this study aims to evaluate the role of membrane-assisted regenerative therapy in the management of PI. A systematic literature search was conducted in PubMed, Scopus, Cochrane Library, and Google Scholar following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines, with the protocol registered in PROSPERO (CRD420251089276). Sixty-nine studies met the inclusion criteria. The primary outcomes assessed were bone-fill gain and reduction in probing pocket depth (PPD). Although some studies reported improved bone-fill and PPD reduction with membrane-assisted regenerative therapy, the findings were not consistently significant. Future research should validate the clinical efficacy of membranes through well-designed randomized trials and develop advanced decontamination techniques and implant surface modifications that could enhance treatment predictability and patient outcomes. Overall, while membranes show potential clinical value in regenerative therapy, their necessity remains uncertain owing to variability in the current evidence.
Keywords: peri-implantitis; decontamination; guided bone regeneration; resorbable membranes; non-resorbable membranes; bone regeneration; re-osseointegration peri-implantitis; decontamination; guided bone regeneration; resorbable membranes; non-resorbable membranes; bone regeneration; re-osseointegration
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MDPI and ACS Style

Cho, Y.J.; Jeong, Y.T.; Woo, H.N.; Cho, H.W.; Kang, M.G.; Hwang, S.-M.; Lee, J.-M. Evaluating the Clinical Efficacy of Membrane-Assisted Regenerative Therapy in Peri-Implantitis Management: A Comprehensive Review Incorporating Systematic Review Evidence. Materials 2025, 18, 5227. https://doi.org/10.3390/ma18225227

AMA Style

Cho YJ, Jeong YT, Woo HN, Cho HW, Kang MG, Hwang S-M, Lee J-M. Evaluating the Clinical Efficacy of Membrane-Assisted Regenerative Therapy in Peri-Implantitis Management: A Comprehensive Review Incorporating Systematic Review Evidence. Materials. 2025; 18(22):5227. https://doi.org/10.3390/ma18225227

Chicago/Turabian Style

Cho, Young Joon, Yong Tak Jeong, Hyun Nyun Woo, Hyun Woo Cho, Min Gu Kang, Sung-Min Hwang, and Jae-Mok Lee. 2025. "Evaluating the Clinical Efficacy of Membrane-Assisted Regenerative Therapy in Peri-Implantitis Management: A Comprehensive Review Incorporating Systematic Review Evidence" Materials 18, no. 22: 5227. https://doi.org/10.3390/ma18225227

APA Style

Cho, Y. J., Jeong, Y. T., Woo, H. N., Cho, H. W., Kang, M. G., Hwang, S.-M., & Lee, J.-M. (2025). Evaluating the Clinical Efficacy of Membrane-Assisted Regenerative Therapy in Peri-Implantitis Management: A Comprehensive Review Incorporating Systematic Review Evidence. Materials, 18(22), 5227. https://doi.org/10.3390/ma18225227

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