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Volume 15
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10.3390/ma15082954
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Article

Biomedical Membrane of Fish Collagen/Gellan Gum Containing Bone Graft Materials

by
Jin Kim
1,†,
Chang-Moon Lee
2,3,4,†,
Seong-Yong Moon
1,
Young-IL Jeong
5,
Chun Sung Kim
6,* and
Sook-Young Lee
7,*
1
Department of Oral and Maxillofacial Surgery, Chosun University Dental Hospital, Gwangju 61452, Korea
2
School of Healthcare and Biomedical Engineering, Chonnam National University, Yeosu 59662, Korea
3
Department of Biomedical Engineering, Chonnam National University, Yeosu 59662, Korea
4
Research Center of Healthcare and Biomedical Engineering, Chonnam National University, Yeosu 59662, Korea
5
The Institute of Dental Science, Chosun University, Gwangju 61452, Korea
6
Department of Oral Biochemistry, College of Dentistry, Chosun University, Gwangju 61452, Korea
7
Marine Bio Research Center, Chosun University, Wando 59146, Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Materials 2022, 15(8), 2954; https://doi.org/10.3390/ma15082954
Submission received: 30 January 2022 / Revised: 15 April 2022 / Accepted: 15 April 2022 / Published: 18 April 2022
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Abstract

The development of a guided bone regeneration (GBR) membrane with non-mammalian fish collagen has the advantage of low risk for transmission of infectious diseases in tissue regeneration. In this work, a fish collagen/gellan gum and bone graft material (FC/GG-BGM) composite GBR membrane were fabricated through solution blending and casting procedures in a vacuum. The membranes were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy observation (SEM), and atomic force microscope (AFM) analyses. FT-IR results suggested that ionic interactions were formed between FC and GG both in composite powder and membranes. In vivo experiments showed that these FC/GG-BGM composite membranes could generate osteoblast minerals and promote loose bone calcification, thus accelerating bone regeneration. At 2 weeks, the defected site of rats treated with FC/GG-BGM membrane (0.377 ± 0.012 mm3) showed higher regeneration than that of rats treated with the bovine collagen membrane (0.290 ± 0.015 mm3) and control rats without membrane (0.160 ± 0.008 mm3). Compared with bovine collagen membrane, the FC/GG-BGM composite membrane displays better bone regeneration ability. Therefore, FC/GG-BGM composite membrane is suitable as a GBR membrane for bone regeneration.
Keywords: fish collagen; gellan gum; bone graft materials; membrane fish collagen; gellan gum; bone graft materials; membrane
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MDPI and ACS Style

Kim, J.; Lee, C.-M.; Moon, S.-Y.; Jeong, Y.-I.; Kim, C.S.; Lee, S.-Y. Biomedical Membrane of Fish Collagen/Gellan Gum Containing Bone Graft Materials. Materials 2022, 15, 2954. https://doi.org/10.3390/ma15082954

AMA Style

Kim J, Lee C-M, Moon S-Y, Jeong Y-I, Kim CS, Lee S-Y. Biomedical Membrane of Fish Collagen/Gellan Gum Containing Bone Graft Materials. Materials. 2022; 15(8):2954. https://doi.org/10.3390/ma15082954

Chicago/Turabian Style

Kim, Jin, Chang-Moon Lee, Seong-Yong Moon, Young-IL Jeong, Chun Sung Kim, and Sook-Young Lee. 2022. "Biomedical Membrane of Fish Collagen/Gellan Gum Containing Bone Graft Materials" Materials 15, no. 8: 2954. https://doi.org/10.3390/ma15082954

APA Style

Kim, J., Lee, C.-M., Moon, S.-Y., Jeong, Y.-I., Kim, C. S., & Lee, S.-Y. (2022). Biomedical Membrane of Fish Collagen/Gellan Gum Containing Bone Graft Materials. Materials, 15(8), 2954. https://doi.org/10.3390/ma15082954

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