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Article

Efficacy of Ciprofloxacin, Metronidazole and Minocycline in Ordered Mesoporous Silica against Enterococcus faecalis for Dental Pulp Revascularization: An In-Vitro Study

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ORALRES Group, Department of Oral Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Travesía da Choupana S/N, 15706 Santiago de Compostela, Spain
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Department of Microbiology and Parasitology, CIBUS-Faculty of Biology, University of Santiago de Compostela, Campus Vida, 15705 Santiago de Compostela, Spain
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MedOralRes Group, Department of Surgery and Medical-Surgical Specialities, Universidade de Santiago de Compostela (USC), Entrerrios S/N, 15705 Santiago de Compostela, Spain
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Institute of Physics, Universidade de São Paulo, Rua do Matão, Sao Paulo 05508-090, SP, Brazil
*
Author to whom correspondence should be addressed.
Academic Editors: Mafalda Laranjo, Eunice Carrilho and Francesco Inchingolo
Materials 2022, 15(6), 2266; https://doi.org/10.3390/ma15062266
Received: 30 December 2021 / Revised: 13 March 2022 / Accepted: 14 March 2022 / Published: 18 March 2022
(This article belongs to the Special Issue Biomaterials Development and Evaluation for Dentistry)
Pulp revascularization of teeth with necrotic pulp has become an alternative treatment in cases with immature apex. Microbial control is essential to achieve a successful outcome and continued root development. Enterococcus faecalis (E. faecalis) is the most frequently isolated bacterial species in root canals of endodontically failed teeth. Our main goal was to compare the in-vitro antimicrobial efficacy of different antibiotic formulations delivered by ordered mesoporous silica (OMS) against E. faecalis. To determine antibiotic susceptibility, we tested OMS and triple antibiotic paste (TAP; ciprofloxacin:metronidazole:minocycline) with different reagents in different concentrations, using the Kirby–Bauer disk diffusion method. OMS and metronidazole showed no antibacterial activity against E. faecalis. Mixtures of OMS and antibiotics in proportions of 2:2:14 and 4:1:7 (mg/L of ciprofloxacin:metronidazole:minocycline, respectively) showed the lowest antibacterial activity. The antibacterial activity of the combined solutions of ciprofloxacin and metronidazole was significantly higher (p < 0.005). Combinations in different concentrations of minocycline, ciprofloxacin, and metronidazole in OMS have shown activity against E. faecalis, although the combined use of ciprofloxacin and metronidazole has shown the most effective results. This study demonstrates the efficacy of intracanal antibiotic combination paste activity against E. faecalis, avoiding the use of minocycline, whose undesirable effect of teeth staining is a common problem for patients and professionals in dental clinic. View Full-Text
Keywords: antibiotics; Enterococcus faecalis; microbial sensitivity tests; pulp revascularization antibiotics; Enterococcus faecalis; microbial sensitivity tests; pulp revascularization
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MDPI and ACS Style

Chamorro-Petronacci, C.M.; Torres, B.S.; Guerrero-Nieves, R.; Pérez-Sayáns, M.; Carvalho-de Abreu Fantini, M.; Cides-da-Silva, L.C.; Magariños, B.; Rivas-Mundiña, B. Efficacy of Ciprofloxacin, Metronidazole and Minocycline in Ordered Mesoporous Silica against Enterococcus faecalis for Dental Pulp Revascularization: An In-Vitro Study. Materials 2022, 15, 2266. https://doi.org/10.3390/ma15062266

AMA Style

Chamorro-Petronacci CM, Torres BS, Guerrero-Nieves R, Pérez-Sayáns M, Carvalho-de Abreu Fantini M, Cides-da-Silva LC, Magariños B, Rivas-Mundiña B. Efficacy of Ciprofloxacin, Metronidazole and Minocycline in Ordered Mesoporous Silica against Enterococcus faecalis for Dental Pulp Revascularization: An In-Vitro Study. Materials. 2022; 15(6):2266. https://doi.org/10.3390/ma15062266

Chicago/Turabian Style

Chamorro-Petronacci, Cintia Micaela, Beatriz Santos Torres, Rocío Guerrero-Nieves, Mario Pérez-Sayáns, Marcia Carvalho-de Abreu Fantini, Luis Carlos Cides-da-Silva, Beatriz Magariños, and Berta Rivas-Mundiña. 2022. "Efficacy of Ciprofloxacin, Metronidazole and Minocycline in Ordered Mesoporous Silica against Enterococcus faecalis for Dental Pulp Revascularization: An In-Vitro Study" Materials 15, no. 6: 2266. https://doi.org/10.3390/ma15062266

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