Synthesis and Anticancer Activity of Bagasse Xylan/Resveratrol Graft-Esterified Composite Nanoderivative
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Preparation of Initiator Solution
2.3. Preparation of EGDMA Monomer Emulsion
2.4. Synthesis of BX/Res–EGDMA Grafted Copolymer
2.5. Synthesis of Esterified Derivatives of 3-CBA-BX/Res-g-EGDMA
2.6. Preparation of Nanoparticles 3-CBA-BX/Res-g-EGDMA
2.7. Determination of Grafting Rate and Monomer Conversion Rate
2.8. Determination of Degree of Substitution
2.9. Characterization
2.10. Molecular-Docking Study
2.11. Tumor-Cell-Proliferation Inhibitory Assay
3. Results and Discussion
3.1. Single-Factor Analysis of Graft Copolymerization Reaction
3.2. Single-Factor Analysis of Esterification Reaction
3.3. Structure Analyses
3.3.1. FTIR Analyses
3.3.2. XRD Analyses
3.3.3. SEM Analyses of 3-CBA-BX/Res-g-EGDMA
3.3.4. TG–DTG Analyses of 3-CBA-BX/Res-g-EGDMA
3.3.5. 1H NMR Analyses of 3-CBA-BX/Res-g-EGDMA
3.4. Molecular-Docking Study
3.5. Inhibition Analyses of Tumor Cell
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sample | PDB Code | |||
---|---|---|---|---|
2HE7 | 5JQI | 5ZSY | 6YAU | |
ΔE (BX) | −4.65 | −3.82 | −3.92 | −4.44 |
ΔE (3-CBA-BX/Res-g-EGDMA) | −6.3 | −3.24 | −3.34 | −3.66 |
Sample | Mass Concentration (μg/mL) | Inhibition Ratio (%) | |||
---|---|---|---|---|---|
NGEC | MGC80-3 | BEL-7407 | NCI-H460 | ||
BX | 100 | 1.81 ± 0.47 | 2.02 ± 0.57 | 1.07 ± 0.71 | 4.62 ± 2.79 |
50 | 1.64 ± 0.69 | 0.24 ± 0.08 | 1.18 ± 0.34 | 0.71 ± 0.22 | |
20 | −0.31 ± 0.52 | −0.15 ± 0.13 | 0.35 ± 0.26 | −0.24 ± 0.19 | |
10 | −3.07 ± 0.33 | −2.99 ± 1.11 | 0.47 ± 0.29 | −2.97 ± 1.43 | |
1 | −5.78 ± 0.20 | −3.27 ± 1.61 | −0.45 ± 0.31 | −4.33 ± 2.03 | |
BX/Res | 100 | 1.53 ± 0.42 | 3.43 ± 1.35 | 2.39 ± 0.58 | 6.81 ± 2.03 |
50 | 1.31 ± 0.57 | 2.14 ± 0.19 | 2.25 ± 0.51 | 4.37 ± 2.64 | |
20 | −0.58 ± 0.33 | 1.57 ± 0.52 | 1.62 ± 0.65 | 2.86 ± 0.41 | |
10 | −3.45 ± 0.41 | 0.76 ± 0.26 | 0.87 ± 0.26 | 1.25 ± 0.36 | |
1 | −5.80 ± 0.54 | −1.34 ± 0.27 | 0.14 ± 0.07 | 0.62 ± 0.37 | |
3-CBA-BX/Res-g-EGDMA | 100 | 2.91 ± 0.57 | 36.71 ± 4.93 | 20.76 ± 2.13 | 25.87 ± 3.28 |
50 | 1.71 ± 0.84 | 32.38 ± 4.16 | 16.39 ± 3.72 | 21.93 ± 4.41 | |
20 | 1.37 ± 0.62 | 28.84 ± 3.79 | 11.87 ± 3.21 | 17.38 ± 3.65 | |
10 | −0.98 ± 0.26 | 21.61 ± 2.83 | 6.95 ± 2.28 | 11.65 ± 3.01 | |
1 | −1.86 ± 0.59 | 16.15 ± 3.61 | 4.63 ± 1.37 | 7.37 ± 2.36 |
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Zhao, B.; Li, H.; Su, Y.; Tian, K.; Zou, Z.; Wang, W. Synthesis and Anticancer Activity of Bagasse Xylan/Resveratrol Graft-Esterified Composite Nanoderivative. Materials 2022, 15, 5166. https://doi.org/10.3390/ma15155166
Zhao B, Li H, Su Y, Tian K, Zou Z, Wang W. Synthesis and Anticancer Activity of Bagasse Xylan/Resveratrol Graft-Esterified Composite Nanoderivative. Materials. 2022; 15(15):5166. https://doi.org/10.3390/ma15155166
Chicago/Turabian StyleZhao, Bin, Heping Li, Yue Su, Kexin Tian, Zhiming Zou, and Wenli Wang. 2022. "Synthesis and Anticancer Activity of Bagasse Xylan/Resveratrol Graft-Esterified Composite Nanoderivative" Materials 15, no. 15: 5166. https://doi.org/10.3390/ma15155166