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Article

Impact of Zinc- or Copper-Doped Mesoporous Bioactive Glass Nanoparticles on the Osteogenic Differentiation and Matrix Formation of Mesenchymal Stromal Cells

1
Center of Orthopedics, Traumatology, and Spinal Cord Injury, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118 Heidelberg, Germany
2
Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany
3
Center for Trauma Surgery, Orthopedics and Sports Medicine, ATORG—Aschaffenburg Trauma and Orthopedic Research Group, Klinikum Aschaffenburg-Alzenau, Am Hasenkopf 1, 63739 Aschaffenburg, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: Andrew Ruys
Materials 2021, 14(8), 1864; https://doi.org/10.3390/ma14081864
Received: 13 March 2021 / Revised: 5 April 2021 / Accepted: 7 April 2021 / Published: 9 April 2021
Mesoporous bioactive glass nanoparticles (MBGNs) have gained relevance in bone tissue engineering, especially since they can be used as vectors for therapeutically active ions like zinc (Zn) or copper (Cu). In this study, the osteogenic properties of the ionic dissolution products (IDPs) of undoped MBGNs (composition in mol%: 70 SiO2, 30 CaO) and MBGNs doped with 5 mol% of either Zn (5Zn-MBGNs) or Cu (5Cu-MBGNs; compositions in mol%: 70 SiO2, 25 CaO, 5 ZnO/CuO) on human bone marrow-derived mesenchymal stromal cells were evaluated. Extracellular matrix (ECM) formation and calcification were assessed, as well as the IDPs’ influence on viability, cellular osteogenic differentiation and the expression of genes encoding for relevant members of the ECM. The IDPs of undoped MBGNs and 5Zn-MBGNs had a comparable influence on cell viability, while it was enhanced by IDPs of 5Cu-MBGNs compared to the other MBGNs. IDPs of 5Cu-MBGNs had slightly positive effects on ECM formation and calcification. 5Zn-MBGNs provided the most favorable pro-osteogenic properties since they increased not only cellular osteogenic differentiation and ECM-related gene expression but also ECM formation and calcification significantly. Future studies should analyze other relevant properties of MBGNs, such as their impact on angiogenesis. View Full-Text
Keywords: mesoporous bioactive glass nanoparticles; zinc; copper; osteogenic differentiation; extracellular matrix mesoporous bioactive glass nanoparticles; zinc; copper; osteogenic differentiation; extracellular matrix
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MDPI and ACS Style

Westhauser, F.; Decker, S.; Nawaz, Q.; Rehder, F.; Wilkesmann, S.; Moghaddam, A.; Kunisch, E.; Boccaccini, A.R. Impact of Zinc- or Copper-Doped Mesoporous Bioactive Glass Nanoparticles on the Osteogenic Differentiation and Matrix Formation of Mesenchymal Stromal Cells. Materials 2021, 14, 1864. https://doi.org/10.3390/ma14081864

AMA Style

Westhauser F, Decker S, Nawaz Q, Rehder F, Wilkesmann S, Moghaddam A, Kunisch E, Boccaccini AR. Impact of Zinc- or Copper-Doped Mesoporous Bioactive Glass Nanoparticles on the Osteogenic Differentiation and Matrix Formation of Mesenchymal Stromal Cells. Materials. 2021; 14(8):1864. https://doi.org/10.3390/ma14081864

Chicago/Turabian Style

Westhauser, Fabian, Simon Decker, Qaisar Nawaz, Felix Rehder, Sebastian Wilkesmann, Arash Moghaddam, Elke Kunisch, and Aldo R. Boccaccini. 2021. "Impact of Zinc- or Copper-Doped Mesoporous Bioactive Glass Nanoparticles on the Osteogenic Differentiation and Matrix Formation of Mesenchymal Stromal Cells" Materials 14, no. 8: 1864. https://doi.org/10.3390/ma14081864

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