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Article

A New Generation of Electrospun Fibers Containing Bioactive Glass Particles for Wound Healing

1
Dipartimento di Ingegneria Enzo Ferrari, Università degli Studi di Modena e Reggio Emilia, Via P. Vivarelli 10, 41125 Modena, Italy
2
Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstr. 6, 91058 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Materials 2020, 13(24), 5651; https://doi.org/10.3390/ma13245651
Received: 24 November 2020 / Revised: 8 December 2020 / Accepted: 9 December 2020 / Published: 11 December 2020
Chitosan fibers blended with polyethylene oxide (CHIT_PEO) and crosslinked with genipin were fabricated by electrospinning technique. Subsequently, CHIT_PEO bioactive glass composite electrospun mats were fabricated with the aim to achieve flexible structures with adequate mechanical properties and improved biological performance respect to CHIT_PEO fibers, for potential applications in wound healing. Three different compositions of bioactive glasses (BG) were selected and investigated: 45S5 BG, a Sr and Mg containing bioactive glass (BGMS10) and a Zn-containing bioactive glass (BGMS_2Zn). Particulate BGs (particles size < 20 μm) were separately added to the starting CHIT_PEO solution before electrospinning. The two recently developed bioactive glasses (BGMS10 and BGMS_2Zn) showed very promising biological properties in terms of bioactivity and cellular viability; thus, such compositions were added for the first time to CHIT_PEO solution to fabricate composite electrospun mats. The incorporation of bioactive glass particles and their distribution into CHIT_PEO fibers were assessed by SEM and FTIR analyses. Furthermore, CHIT_PEO composite electrospun mats showed improved mechanical properties in terms of Young’s Modulus compared to neat CHIT_PEO fibers; on the contrary, the values of tensile strain at break (%) were comparable. Biological performance in terms of cellular viability was investigated by means of WST-8 assay and CHIT_PEO composite electrospun mats showed cytocompatibility and the desired cellular viability. View Full-Text
Keywords: chitosan; electrospinning; bioactive glasses; composite fibers; mechanical properties; wound healing chitosan; electrospinning; bioactive glasses; composite fibers; mechanical properties; wound healing
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MDPI and ACS Style

Sergi, R.; Cannillo, V.; Boccaccini, A.R.; Liverani, L. A New Generation of Electrospun Fibers Containing Bioactive Glass Particles for Wound Healing. Materials 2020, 13, 5651. https://doi.org/10.3390/ma13245651

AMA Style

Sergi R, Cannillo V, Boccaccini AR, Liverani L. A New Generation of Electrospun Fibers Containing Bioactive Glass Particles for Wound Healing. Materials. 2020; 13(24):5651. https://doi.org/10.3390/ma13245651

Chicago/Turabian Style

Sergi, Rachele, Valeria Cannillo, Aldo R. Boccaccini, and Liliana Liverani. 2020. "A New Generation of Electrospun Fibers Containing Bioactive Glass Particles for Wound Healing" Materials 13, no. 24: 5651. https://doi.org/10.3390/ma13245651

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